非洛地平缓释片与硝苯地平治疗轻中度高血压病的对照试验

Comparison between the Effects of Felodipine and Nifedipine on Mild and Moderate Hypertension

将106例轻、中度高血压病人分为两组.非洛地平缓释片组50例,每日早餐后口服5～10mg,疗程4周;对照药硝苯地平组56例,10～20mg,tid,口服,疗程4周.非洛地平组降血压显效率68%,总有效率88%,显著高于硝苯地平组(P<0.05);降压幅度两组间差异有显著性(P<0.05);不良反应多为轻度且一过性,主要有潮红、头痛、踝肿,以非洛地平组较轻.

106 patients with mild and moderate hypertension were divided into 2 groups, with 50 in felodipine group and 56 in nifedipine group. The felodipine group was orally given slow-releasing tablets of 5 ~10 mg after breakfast and the nifidipine group was orally given nifedipine of 10-20 mg, 3 times a day. The treatment lasted for 4 weeks. The Felodipine group showed a total effective rate of 88%, which was significantly higher than that of nifedipine group (P<0.05). There was a significant difference in blood pressure lowering effect between two groups. The adverse reactions were mostly transient, mainly including flush, headache, ankle swelling and they were mild in felodipine group.