2型糖尿病血清β_2-微球蛋白的临床意义

Globulin In Serum

目的探讨2型糖尿病与血清β2-微球蛋白的关系。方法采用放射免疫分析法对30例正常人,72例2型糖尿病人(其中早期糖尿病肾病35例,简写为DN,糖尿病未出现肾损害37例,简写为NDN)进行血清β2-微球蛋白测定,并分组进行分析。结果DN组血清β2-微球蛋白含量明显高于对照组,P<0.01,差异有显著性,对照组、NDN组及DN组血清β2-微球蛋白的含量逐渐递增,NDN组与对照组相比,P>0.05,差异无显著性。结论血清β2-微球蛋白在DN组明显升高,提示该指标对预测早期糖尿病肾病有重要意义。

Objective To investigation the relationship between type 2 diabetes mellitns and β2-micro globulin in serum.Methods Measuring the content of the serum β2-micro globulin in 72 patients with type 2 diabetes mellitus （35 with diabetes nephropathy, DN and 37 without nephropathy,NDN） using radiation immunity analysis（RIA）,to compare with those of control group including 30 patients and analyzing them in groups.Results The contaiut of β2-micro globulin in serum in diabetes nephropathy higher than that in the control group,P〈0.01,with the difference significant,the containt from the control group to NDN and DN increasing gradually,that in NDN compared with that in the control group,P〉0.05,with the difference insignificant.Conclusion The serum β-micro globulin in diabetes nephropathy is more higher,meaning it is more important to forecasting diabetes nephropathy.