FOLFOX4方案治疗晚期胃癌疗效观察

Clinical Report of FOLFOX4 Regimen in Treatment of Patients with Advanced Stomach Cancer

目的观察L-OHP联合CF和5-Fu治疗晚期胃癌的临床疗效和毒副反应。方法32例晚期胃癌患者,L-OHP130mg/m2,静脉滴注2h,d1;CF200mg/m2,静脉滴注2h,d1～5;5-Fu500mg/m2,静脉滴注>6h,d1～5;21d为1周期。进行3周期后评价疗效。结果32例患者中CR3例,PR13例,SD9例,PD7例,CR+PR48.4%,毒副反应以骨髓抑制、感觉神经毒性为主,白细胞下降发生率为62.5%,神经毒性发生率为40.6%,无Ⅳ度毒副反应。结论L-OHP、CF、5-Fu联合应用治疗晚期胃癌疗效肯定,毒副反应轻,耐受性好。

Objective To observe the chemotherapy effic ay and toxicity of FOLFOX4 regimen on advanced stomach cancer. Methods 32 patients whith advanced stomach cancer received therapy,L-OHP 130mg/m^2 ivgtt within 2h,d1,CF 200mg/m^2 ivgtt within 2h, d1-5,5-Fu 500mg/m^2 ivgtt longer than 6h, d1-5,The treanment was repedated every 3 weeks for 3 cycles. Results 32 cases could evaluate efficaey, the complete respons and partial response were observed in 3 and 13 case respectively. The overall response rate was 48.4% ,The main adverse reactions were neurtoxicity andbone marrow depression. Conclusion L-OHP combined with 5-Fu/CF is an effective and well tolerated regimen in the treatment of advanced stomach cancer, which can relieve symptoms and improve quality of life of the patients.