老年患者认知功能障碍与动脉僵硬度关系

Relationship between cognitive impairment and arterial stiffness in elderly patients

目的探讨老年患者认知功能障碍与动脉僵硬度的关系。方法选择142例老年患者，以肢体动脉搏动波（PWV）作为评价动脉僵硬度指标，以简易精神状态量表（MMSE）作为认知功能评价指标，MMSE评分总分30分，评分％24分为认知功能障碍。对所有人选病例进行PWV检查及MMSE评分，根据MMSE评分将所有患者分为两组：认知功能正常组93例，认知功能障碍组49例。结果认知功能障碍组较认知功能正常组PWV明显增高[（13．3±2．4）m／s与（11．8±2．2）m／s，t=3．775，P=0．0003。经Logistic回归分析，MMSE评分与PWV呈显著相关。结论动脉僵硬度增加是老年患者认知功能障碍重要危险因素。

Objective To explore the relationship between cognitive impairment and arterial stiffness in elderly patients. Methods A total of 142 elderly patients were enrolled. Cognitive function was assessed by mini mental state examination （MMSE） and arterial stiffness was assessed by pulse wave velocity （PWV）. A full score on the MMSE was 30, and cognitive impairment was defined as a score less than 24. All subjects underwent the measurement of PWV and MMSE . The subjects were divided into 2 groups： 93 were assigned to the normal cognitive function group （MMSE score 24）, and the remainders （n=49） were assigned to the cognitive impairment group （MMSE score 24）. Results The PWV was significantly increased in the cognitive impairment group than in the normal cognitive function group [（13.3±2.4）m/s vs. （11.8±2.2）m/s, t=3.775,P=0.000]. Logistic regression analysis showed that the PWV was also independently and significantly associated with the MMSE score. Conclusions The increase of arterial stiffness is an important risk factor for impaired cognitive function in elderly patients.