肺心病与红细胞免疫功能及促红细胞生成素含量的相关性研究

Correlation of pulmonary heart disease with erythrocyte immunity function and serum erythropoietin level

目的探讨肺心病与红细胞免疫功能及促红细胞生成素（EPO）含量的相关性。方法选择肺心病患者48例，对照组40例，以酵母菌花环法、酶联免疫吸附试验（ELISA）分别测定两组血液的红细胞C3b受体花环率、红细胞免疫复合物花环率和EPO含量，用血气分析仪进行血气分析。结果肺心病组患者的红细胞C3b受体花环率及血中EPO含量均较对照组降低，免疫复合物花环率较对照组升高。动脉血气分析中二氧化碳分压（PCO2）和碳酸氢根（HCO3^-）较对照组明显升高，血氧饱和度（SaO2）较对照组降低，而血pH值及氧分压（PO2）则较对照组无明显变化。肺心病组患者红细胞C3b受体花环率与血清EPO含量呈正相关（r=0．623，P〈0．01）；HCO3^-与pH值和PCO2呈正相关（r=0．219，P〈0．05；r=0．585，P〈0．01）；PCO2与pH值呈负相关（r=0．529，P〈0．01）；PO2与SaO2呈正相关（r=0．682，P〈0．01）。结论肺心病患者红细胞C3b受体花环率与血清EPO含量存在相关关系。

Objective To explore the correlation of pulmonary heart disease （PHD） with erythrocyte immunity function and serum erythropoietin（EPO）level. Methods Forty-eight patients with PHD were selected as PHD group, while forty people were chosen as control group. The erythrocyte C3h receptor （E-C3bRR）, erythrocyte immunity complex （RBC-ICR） and serum EPO content were detected by yeast rosette method and enzyme-linked immunosorbent assay （ELISA）,and blood gas indexes were examined by blood gas analyser. Results The E C3bRR and serum EPO content were lower, while the RBC ICR was higher in PHD group than in control group（both P〈0.01）. Compared with control group, PCO2 and HCO3^- levels were higher, but blood oxygen saturation（SaO2） level was lower in the PHD group than in control group（both P〈0.01）. There were no differences in pH value and PO2 between two groups（both P〉0.05）. The E C3bRR was positively related to serum EPO content（r=0. 623, P〈0.01） ,and HCO3^- was positively related to pH value and PCO2 （r=0. 219 ,P〈0.05;r=0. 585 ,P〈0.01 ）, whereas PCO2 was negatively related to pH value（r=0. 529,P〈0.01）,and PO2 was positively related to SaO2 （r=0. 682,P〈0.01）in PHD group. Conclusions There is a correlation between E-C3bRR and serum EPO content in PHD patients.