脂类对非酒精性脂肪性肝病发生的影响

Effect of Lipids on the Development of Nonalcoholic Fatty Liver Disease

作为代谢综合征重要组分之一的非酒精性脂肪性肝病（NAFLD）在肥胖、2型糖尿病和高脂血症人群中有着相当高的发病率．如不予及时干预，将给人类健康带来巨大威胁。脂质在肝脏异常异位蓄积是NAFLD发生的主要原因，其中起重要作用的脂类主要包括三酰甘油、胆固醇和脂肪酸。这些脂质来源各异，分别在NAFLD肝细胞脂肪变性的不同阶段发挥作用。本文就不同脂类在NAFLD发生中的作用作一综述。

As an important constituent of metabolic syndrome, nonalcoholic fatty liver disease （NAFLD） has a high incidence rate in people with obesity, type 2 diabetes and hyperlipidemia. It causes big problems to people＇s health if without intervention. The most important etiological factor of NAFLD is the ectopic accumulation of lipids in the liver. Lipids from different sources, including mainly triglycerides, cholesterol and fatty acids, play roles in different phases of nonalcoholic fatty degeneration. In this article, we reviewed their roles in the development of NAFLD.