期刊文献+

葛根素在大鼠体内的排泄过程与给药途径的相关性 被引量:2

Study on the correlation between excretion of puerarin and administration routes in rats
下载PDF
导出
摘要 目的比较葛根素不同途径给药后的排泄过程。方法大鼠经静脉或灌胃给予葛根素后,按一定时间段收集尿和粪便,以高效液相色谱荧光光谱法检测尿和粪样中的葛根素。结果给大鼠灌胃葛根素混悬液后,葛根素由粪便中排泄的累积排泄率为41.56%,其中4~8h由粪便排泄量占由粪便排泄葛根素总量的75.26%,8~12h的排泄量占23.99%;12h内由尿中排泄的葛根素占给药量的0.64%,0~4h、4~8h葛根素由尿的排泄量分别占由尿排泄总量的27.91%和66.28%;24h内经粪便中排泄的葛根素约占排泄总量的98.40%。大鼠经尾静脉注射葛根素注射液24h内,葛根素由尿中排泄的累积排泄率为36.15%,而其中的97.43%是在前4h内排泄的;由粪便中排泄的葛根素占给药量的9.18%,而其中的99.19%是在给药后的8~12h之间排出的;24h内经尿中排泄的葛根素占排泄总量的79.64%。结论葛根素的排泄与给药途径有关,大鼠灌胃给药后,葛根素主要经肠道排泄,而经静脉给药后,葛根素主要经肾脏排泄。 OBJECTIVE To investigate the different excretive process of puerarin after different administration routes in rats. METHODS Puerarin was administrated intragastricly or intravenously, and urine and feces were collected, puerarin in excreta was determinated by high performance liquid chromatography with fluorescence detection. RESULTS When puerarin suspension was administrated orally in rats, the cumulative rate of excretion in feces was 41.56 %, the excretive amount during 4--8h was 75.26 % of overall amount excreted in feces, and that during 8~12h was 23.99 % ; the cumulative rate of excretion in urine was 0.64 % ; the excretive amount during 0 4h and 4~8h was 27.91% and 66.28 % of overall amount excreted in urine; the excretive amount in feces was 98.40 % of overall excretive amount. When puerarin was administrated intravenously in rats, the cumulative rate of excretion in feces was 9.18 %, the excretive amount during 8~12h was 99.19 % of overall amount excreted in feces;the cumulative rate of excretion in urine was 36.15% ; the excretive amount in 4h was 97.43% of overall amount excreted in urine;the excretive amount in urine was 79.64 % of overall excretive amount. CONCLUSION The excretion of puerarin was correlated to administration, puerarin was mainly excreted by intestinal tract after intragastric administration, but it was mainly excreted by kidney after intravenous administration.
出处 《海峡药学》 2009年第4期41-44,共4页 Strait Pharmaceutical Journal
基金 国家"863"计划资助项目(2007AA022002) 广州市科技局资助项目(2007Z3-E5051)
关键词 葛根素 排泄 高效液相色谱荧光光谱法 Puerarin excretion High performance liquid chromatography Fluorescence detection
  • 相关文献

参考文献7

  • 1Yan LP, Chan SW, Chan ASC, et al.Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats [J] .Life Sci, 2006, 79(4) : 324-330.
  • 2宋雪鹏 陈平平 柴象枢.葛根索对自发性高血压大鼠的降压作用及对其血浆肾素活性的影响.中国药理学报,1988,9(1):55-58.
  • 3Hsu FL, Liu IM, Kuo DH, et al. Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats[J] .J Nat Prod, 2003, 66(6) : 788-792.
  • 4Xu ME, Xiao SZ, Sun YH, et al. The study of anti-metabolic syndrome effect of puerarin in vitro[J]. Life Sci, 2005, 77(25) :3183-3196.
  • 5王莉,邢东明,卢弘,孙虹,何希辉,杜力军.CBN中有效成分葛根素在大鼠体内的排泄[J].中药药理与临床,2001,17(5):8-10. 被引量:6
  • 6周冬菊,赵会英,杨英禄.大鼠小肠对葛根素吸收的动力学研究[J].北京化工大学学报(自然科学版),2006,33(5):106-108. 被引量:19
  • 7黄沛,杨中林.不同纯度葛根素提取物的大鼠小肠吸收动力学研究[J].海峡药学,2008,20(3):43-45. 被引量:4

二级参考文献12

共引文献24

同被引文献48

引证文献2

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部