一种模拟生理层流及致病紊流的流动腔系统的应用

Application of Parallel Plate Flow Chamber System Imitating Physiological Laminar Flow and Turbulent Flow

目的运用流动腔在体外模拟出生理层流及致病紊流,从而建立体外流体模型。方法通过对传统流动腔中的硅胶膜垫片的改造,利用蠕动泵调节流量的大小从而获得不同类型的流场。通过FLUENT软件对流场进行计算分析。结果1.5 mL/min紊流组流场剪切力最大的部位是狭窄部位,为2.2 dyn/cm2;1.5 mL/min层流组流场大部分区域剪切力为1.2 dyn/cm2;6.0 mL/min层流组流场大部分区域剪切力为9 dyn/cm2。结论通过调整流量及膜的形态得到了3种不同流场,并通过软件分析证明其分别为低剪切力层流、低剪切力紊流、高剪切力层流。

Objective To simulate 3 kinds of conditions of flow in vitro by using parallel plate flow chamber. Methods By adjusting flux and altering the structure of the traditional flow chamber system we obtain different kinds of conditions of flow. Then we analyse and evaluate the flow conditions by using computational fluid dynamics （ CFD） software to simulate the enclosed flow chamber system. Results In 1.5 mL/min low shear stress turbulent flow group,the largest Shear stress is 2.2 dyn/cm^2. In 1.5 mL/min low shear stress laminar flow group, the Shear stress is 1.2 dyn/cm^2. In 6.0 mL/min low shear stress laminar flow group,the Shear stress is 9 dyn/cm^2. Conclusion We have built 3 kinds of flow conditions including： low shear stress turbulent flow, low shear stress laminar flow and high shear stress laminar flow. The analysis showed the characteristic of these flow conditions was consistent with the trait of the blood flow in vivo.