2型糖尿病患者血8-羟基脱氧鸟嘌呤水平与大血管并发症的关系

Relationship between serum levels of 8-OHdG and macrovascular complications in type-2 diabetes patients

目的初步探讨氧化应激在2型糖尿病患者大血管并发症中的作用。方法 2型糖尿病患者78例,分为大血管并发症组(32例)和无并发症组(46例)。检测两组患者血TG、TC、LDL-C、HDL-C、糖化血红蛋白(HbAlc)和8-羟基脱氧鸟嘌呤(8-OHdG)水平。同期检测65例健康体检者(对照组)血8-OHdG水平。结果 2型糖尿病患者血8-OHdG水平明显高于对照组[(2.78±1.33)μg/L vs (0.72±0.93)μg/L,P<0.05]。大血管并发症组血8-OHdG据平较无并发症组有上升趋势,但差异无统计学意义[(2.93±1.37)μg/L vs (2.67±1.30)μg/L,P>0.05];大血管并发症组TG水平和病程明显高于无并发症组,差异有统计学意义(P<0.05)。血8-OHdG水平与TG和病程呈正相关(P<0.05),而与TC、LDL-C、HDL-C及HbAlc水平无明显相关(P>0.05)。结论 2型糖尿病患者氧化应激水平增高。2型糖尿病患者大血管并发症的发生可能与病程、血脂关系更密切,脂代谢异常是糖尿病氧化应激的重要影响因素。

Objective To investigate the role of oxidative stress in type-2 diabetes patients with macrovascular complications. Methods Serum levels of TG, TC, LDL-C, HDL-C, HbAlc and 8-OHdG were examined in 32 cases of type-2 diabetic patients with macrovascular complications and 46 patients without any complications. 8-OHdG levels in 65 healthy adults were also examined as control. Results The level of 8-OHdG in type-2 diabetic patients[（2.78±1.33）μg/L] was higher than that in the controls[（0.72±40.93）μg/L] ,the difference was significant. 8-OHdG level in type-2 diabetic patients with macrovascular complications was higher than that in patients without complications [（2. 93±1. 37）μg/L vs （2.67±1.30） μg/L], but the difference was not significant. The TG level and course of disease were also higher obviously in patients with macrovascular complications, the difference was significant. Spearman regression analysis showed that the 8-OHdG level was positively correlated with TG and course of disease （P 〈 0. 05）, while there was no obvious correlation with TC, LDL-C, HDL C and HbAlc levels. Conclusions The level of 8-OHdG in type-2 diabetic patients is increased significantly. The course of disease and lipid level are closely related with type-2 diabetes with macrovascular complications. Abnormal lipid metabolism is the important influential factor of oxidative stress in diabetes.