Tibolone对去势裸鼠人子宫内膜癌皮下移植瘤生长及转移的影响

Effect of Tibolone on the Growth of Subcutaneous Xenograft Tumor of Human Endometrial Carcinoma in Castration Nude Mice

目的研究Tibolone对去势裸鼠人子宫内膜癌皮下移植瘤生长及转移的影响,探讨Tibolone治疗子宫内膜癌的安全性.方法建立去势裸鼠人子宫内膜癌皮下移植瘤模型,比较Tibolone灌胃组和对照组给药前后肿瘤体积变化和转移状况.结果Tibolone灌胃组和安慰剂组裸鼠子宫内膜癌皮下移植瘤体积增加值相同(1.976±1.350)mm3和(2.217±1.071)mm3,P=0.879;Tibolone灌胃组(35 d)后,没有引起肿瘤转移.

Objective To explore the safety of tibolone in treatment of human studying the effect of tibolone on the growth of subcutaneous xenograft tumor of human endometrial carcinoma endometrial carcinoma castration nude mice. Methods Established human Ishikawa endometrial carcinoma xenografts by in in ovariectomized bulb/c nude mice were fed with tibolone [0.375 mg/（kg·d）] or placebo for 35 days. The tumor volume between pre-treatment and post-treatment in tibolone group as well as treated group and control group were compared. Results There was no significant difference in the increase of tumor volume in nude mice between tibolone group and control group （1.976±1.350） mm^3, （2.217±1.071 ） mm^3; P = 0.879） ; Tibolone did not induce tumor metastasis. Conclusion Tibolone does not stimulate the growth of endometrial carcinoma cell line Ishikawa xenografts in castration nude mice.