子宫内膜癌预后因素与PTEN表达的相关性

Correlation between Expression of PTEN and Prognostic Features of Patients with Endometrioid Adenocarcinoma

目的分析子宫内膜癌中PTEN蛋白表达与临床及病理因素间的关系,探讨PTEN在子宫内膜样腺癌预后中的作用.方法回顾分析73例子宫内膜样腺癌患者的临床病理参数,并应用免疫组化法检测患者肿瘤标本中PTEN蛋白的表达,分析PTEN与内膜癌主要预后高危因素,如临床分期、子宫肌层浸润深度及淋巴转移的关系.结果PTEN在子宫内膜癌中的阳性表达率为46.6%,PTEN蛋白的表达与主要预后高危因素如细胞分化程度(P=0.088)、子宫肌层浸润深度(P=0.721)、淋巴结转移(P=1.000)、手术分期(P=0.299)雌孕激素受体表达(P=0.204,1.000)等均无显著性相关.结论PTEN表达与内膜癌主要预后高危因素之间可能无关,PTEN在内膜样腺癌预后中的作用需要进一步研究.

Objective To analyze the correlation between expression of PTEN and prognostic features of patients with endometrioid adenocarcinoma, and to investigate the effect of PTEN on predicting risk factors of endometrioid adenocarcinoma. Methods Clinic pathologic data of 73 patients with endometrioid adenoearcinoma were retrospectively analyzed. The expression of PTEN was detected by SP immunohistoehemistry technique, relationship between PTEN and high risk factors, such as clinical stage, myometrium invasion and lymphatic metastasis, was analyzed. Rusults The positive rate of PTEN was 46.6% in the 73 endometrioid adenoearcinoma patients. The expression of PTEN had no correlation to histological differentiation （P = 0.088） , myometrium invasion （P= 0.721）, lymphatic metastasis （P = 1.000）, surgical stage （P= 0.299）, estrogen receptor （P = 0.204） and progestin receptor （P = 1.000） , respectively. Conclution The expression of PTEN is not correlated with mostly predicting high risk factors in patients with endometrioid adenoeareinoma., the effect of PTEN on predicting risk factors of endometrioid adenocareinoma need further study.