腹水超滤过浓缩后腹腔回输治疗肝硬化顽固性腹水15例报告

Treatment of 20 Patients with Liver Cirrhosis Refractory Ascites by Using Reinfusion of Ultrafiltration and Concentration Ascites to Abdominal Cavity

目的应用腹水超滤过浓缩后腹腔回输技术治疗顽固性腹水的临床研究.方法15例顽固性腹水为研究对象,在回输过程中将腹水连接引入回输机,超滤浓缩腹水后回输回腹腔.观察回输前后腹围、体重、尿量、血浆蛋白以及尿素氮,电解质钾,钠,氯的变化.结果治疗15例共20次,腹水消退率达100%.腹水回输后腹围、体重显著下降(P<0.05);尿量、血浆蛋白显著增加(P<0.05);腹水回输前后尿素氮,电解质钾,钠,氯无明显改变(P>0.05),无严重不良反应发生.结论腹水超滤过浓缩后腹腔回输治疗顽固性腹水的方法操作简便,见效快,疗效好,副作用少.

Objective To study effects of treatment of patients with liver cirrhosis refractory ascites by using reinfusion of ultrafiltration and concentration ascites to abdominal cavity. Methods 15 patients with refractory ascites were enrolled in this research. We observed the anterior and posterior therapeutic change of abdominal perimete, body weight, urinary volume, plasma protein, urea nitrogen and electrolytes potassium, sodium, chlorine. In the therapeutic process, ascites was inducted to the reinfusion machine, and reinfused to abdominal cavity after ultrafiltration and concentration. Results We performed 20 uhrafiltration and reinfusion in 15 patients during hospitalization, and the ascites regression rate was 100%. After therapy, body weight decreased significantly （p 〈 0.05） , urinary volume, plasma protein increased significantly （p 〈 0.05） ; but urea nitrogen, electrolytes potassium, sodium, chlorine did not change significantly （p 〉 0.05） , and no severe adverse reaction was detected. Conclusions The treatment of patients with liver cirrhosis refractory ascites by using reinfusion of uhrafiltration and concentrated ascites to abdominal cavity is convenient to manipulate, works quickly, effects well and has little adverse effects.