摘要
目的探讨肥胖儿童血浆增食欲素A水平的改变及其与能量摄入的相关性。方法肥胖组儿童48例,检测患儿空腹外周血中增食欲素A水平、体质量指数(BMI)、能量摄入量,并与48例性别、年龄匹配的健康儿童(健康对照组)进行比较。分析2组血浆增食欲素A水平与BMI、能量摄入的相关性。结果1.肥胖组儿童血浆增食欲素A水平显著低于健康对照组(F=5.632 P=0.008);2.肥胖组儿童血浆增食欲素A水平与BMI呈负相关(r=-0.478 P=0.012),与总能量、脂肪、蛋白质摄入量均呈正相关(r=0.503,0.659,0.381 P=0.007,0.006,0.026),与碳水化合物摄入量呈负相关(r=-0.316 P=0.022);3.健康对照组儿童血浆增食欲素A水平与BMI呈负相关(r=-0.491 P=0.018),与总能量、脂肪、蛋白质摄入量均呈正相关(r=0.512,0.406,0.313P=0.009,0.005,0.020),与碳水化合物摄入量呈正相关(r=0.432 P=0.025)。结论增食欲素A参与了肥胖儿童的能量代谢,增食欲素A与能量摄入存在相关性,而且在不同的营养状态下这一作用不同。
Objective To explore the change of plasma orexin A concentration and the correlation between plasma orexin A concentration and energy intake in obese children. Methods Fasting plasma orexin A concentrations,boaly mass index(BMI) and energy intake were measured in 48 obese children (obese group) and 48 healthy children( healthy control group) , and these indexes were compared, the correlation between plasma orexin A concentration and BMI,energy intake were analyzed. Results 1. The plasma orexin A concentration in obese group was significantly lower than that in healthy control group ( F = 5. 632 P = 0. 008 ). 2. In obsess group, there were negative correlation between plasma orexin A concentration and BMI(r = -0. 478 P = 0. 012) , positive correlation between plasma orexin A concentration and total energyintake(r=0.503 P=0.007),fat intake(r=0.659 P=0.006) and protein intake ( r = 0. 381 P=0.026),and there was negative correlation between plasma orexin A concentration and carbohydrate ( r = - 0.316 P = 0. 022 ). 3. In healthy control group, there were negative correlation between plasma orexin A concentration and BMI ( r = - 0. 491 P = 0.018 ) , positive correlation between plasma orexin A concentration and total energy intake(r=0.512 P=0.009) ,fat intake(r =0.406 P =0.005) ,protein intake(r =0.313 P = 0. 020) , and carbohydrate( r = 0. 432 P = 0. 025 ). Conclusions Orexin A may be involved in regulation of energy metabolism in obese children, and the interaction between plasma orexin A and energy intake might be different in different nutritional status in children.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2009年第8期596-597,600,共3页
Journal of Applied Clinical Pediatrics
基金
深圳市科技计划基金项目资助(2005147)