2-取代环戊(烯)酮芳胺Mannich碱的合成及其抗炎活性

Synthesis and Antiinflammatory Activity of 2Substituted Cyclopentanone or 2Cyclopentenone Mannich Bases from Aromatic Amines

合成了７个未见文献报道的２取代环戊（烯）酮芳胺Ｍａｎｎｉｃｈ碱，证实含强吸电子基团的芳胺可以和脂肪胺Ｍａｎｎｉｃｈ碱进行胺交换反应．采用二甲苯致小鼠耳廓肿胀模型对目标化合物的抗炎活性进行了初步筛选，发现部分化合物有较强的抗炎活性．

Seven new 2(E)pentylidene5(Narylamino methyl)cyclopentanones and 2pentyl5(Narylamino methyl) 2cyclopentenones were synthesized and investigated for antiinflammatory activity.It was confirmed that amine exchange reaction between the Mannich base of aliphatic amine and the arylamine containing electronattracting groups could take place when heated or refluxed.Pharmacological tests showed that some compounds had potent inhibitory effect on xyleneinduced mice′s ear edema.