抗孕新药西替考马的全合成

The Total Synthesis of Centchroman

对西替考马（ｃｅｎｔｃｈｒｏｍａｎ）合成路线进行了改进．其中在ＦｒｉｅｄｅｌＣｒａｆｔｓ烷基化反应中高选择性的获得反式异构体，从而避免了文献报道中的高压氢化和构型转化两个反应单元．共五步反应获到最终产物，收率达４０％．

The synthesis of Centchroman has been improved.The key step is that the desired transisomer was obtained in highly stereoselective FriedelCrafts alkylation.Centchroman was got in five steps with overall yield of 40%.