中重度慢性阻塞性肺疾病患者脑循环动力学变化及其相关因素分析

The change of cerebrovascular activity in patients with chronic obstructive pulmonary disease

目的：探讨中重度慢性阻塞性肺疾病（COPD）患者脑循环动力学（CVA）的变化及其相关因素。方法：对50例中重度COPD患者行CVA、血气分析、血液流变学、纤维蛋白原（Fg）检测,设正常对照组30例,行CVA检测,分别列表对照分析。结果：COPD组较正常对照组CVA参数有明显异常改变,差异有统计学意义（P〈0.05~0.01）。缓解期患者较急性发作期时CVA参数有明显改善,差异有统计学意义（P〈0.05~0.01）。对CVA参数影响显著的因素依次为Fg↑、血黏度↑、二氧化碳分压升高（PaCO2↑）、动脉氧分压降低（PaO2↓）、红细胞压积增大等。结论：中重度COPD患者CVA存在异常改变,且随病情加重而加重,并与血黏度、纤维蛋白原等指标密切相关。

Objective：To investigate the change of cerebrovascular activity（CVA） in patients with chronic obstructive pulmonary disease.Methods：The CVA,blood gas analysis,blood rheology,fibrinogen were determined in 50 patients and CVA was determined in 30 healthy subjects as control.Results： There were significant differences in CVA between the two groups（P〈0.05~0.01）;CVA parameters revealed a marked amelioration during the remission phase as compared with acute episode phase（P〈0.05~0.01）.The factors influencing COPD in the descending order were high levels of blood rheology,fibrinogen and PaCO2,low levels of PaO2,and high levels of blood viscosity and hematocrit.Conclusions： There are abnormal changes of CVA in patients with COPD and the changes are linked with the state of the illness.It is positively correlated with the high level of blood viscosity,,fibrinogen et al.