47例强化口服水化治疗预防造影剂相关性肾损伤的效果探讨

Effect of Intensive Oral Hydration on Preventing Contrast-induced Renal Impairment in patients undergoing Coronary Angiography or Percutaneous Coronary Intervention

目的：探讨强化口服水化治疗预防冠状动脉介入术后造影剂相关肾损伤的效果。方法：采用非随机分组类实验研究,将研究对象分为自由饮水组（对照组）47例和强化饮水组（强化组）47例,比较两组术前、术后血清β2-微球蛋白、尿微量白蛋白、24小时出入量及有无尿潴留、胃部不适等情况。结果：强化组术后3小时入量、术后0~6小时尿量显著高于对照组,强化组术后第1天尿微白蛋白显著低于对照组（P〈0.05）。结论：术后3小时内强化饮水可预防冠状动脉介入术后造影剂相关肾损伤。

Objective：To investigate the effect of intensive oral hydration on preventing contrast-induced renal impairment in patients undergoing coronary angiography（CAG） or percutaneous coronary intervention（PCI）.Methods：With quasi-experimental design,94 patients receiving CAG or PCI were divided into 2 groups according to the recruiting time.The control group adopted routine oral hydration protocol and the experimental group adopted intensive oral hydration protocol.The preoperative and postoperative plasma level of plasma β2 microglobin and urine albumin level,and postoperative 24 hours fluid intake and output volume,incidence of urine retention and stomach uncomfortness were collected and analyzed.Results： Comparing to that of the control group,postoperative 0-3 hours fluid drinking volume of the experimental group was significantly higher with the total postoperative 24 hours drinking volume kept similar（P〈0.05）.Postoperative 0-6 hours urinary volume of the experimental group was significantly higher than that of control group（P〈0.05）.The urea albumin level of the first post-operation day of the experimental group were significantly lower than that of the control group（P〈0.05）.Conclusions： Intensive oral hydration treatment with the first 3 hours after operation could reduce patients＇ contrast-induced renal impairment.