摘要
目的:观察健脾理气方对肝硬化及癌变的预防作用。方法:以DEN诱发大鼠肝硬化伴癌前期病变为模型,生理盐水为对照。观察项目包括病理形态与生化学指标。结果:用中药后肝纤维化程度减轻;肝细胞增生灶与假小叶减少,肝组织GGT阳性灶和AFP阳性细胞、肝组织Hyp和肝细胞DNA含量均减少;肝组织GGT比活性降低。结论:健脾理气方能同时延缓肝硬化的形成与阻制癌前期的病变,其防癌机制可能在于药物抑制了肝细胞DNA的复制。
Aims: To observe the preventing effect of jian Pi Li Qi (JPLQ) decoction on cirrhosis and carcinoma. Methods: The model of cirrhosis and precarcinoma was induced by diethylni-trosamine in rats, normal saline was as the control. The liver pathologic changes and biochemical indexes were observed. Results: The degree of liver fibrosis was abated after application of JPLQ decoction, hepatoctye proliferation focal and pseudolobul were reduced, GGT positive liver tissue focal, AFP positive cells , HyP in liver tissue , DNA content of hepatoctye and liver tissue GGT specific activity were decreased. Conclusions: Jian Pi Li Qi decoction could simultaneously postpone formation of cirrhosis and block precarcinoma. The mechanism of JPLI decoction action maybe associated with inhibition of DNA replication in hepatocytes.
出处
《中西医结合肝病杂志》
CAS
1998年第1期20-23,共4页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases