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他汀类药物在多发性硬化和实验性自身免疫性脑脊髓炎治疗中的应用 被引量:2

The Beneficial Effects of Statins in the Treatment of Multiple Sclerosis
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摘要 大量动物实验证实,他汀类药物可抑制实验性自身免疫性脑脊髓炎(EAE),临床证据也表明他汀类药物能够在多发性硬化(MS)发病的免疫环节中发挥治疗作用.他汀类药物治疗MS的应用前景较为广阔. A large number of animal experiments confirmed that statins can inhibit experimental autoimmune encephalomyelitis (EAE), clinical evidence suggests that statins can play therapeutic effects in multiple sclerosis (MS). Statin treatment of MS has a wider application prospect.
出处 《山西大同大学学报(自然科学版)》 2009年第2期45-47,65,共4页 Journal of Shanxi Datong University(Natural Science Edition)
基金 人事部2006年度回国人员科技活动择优资助项目[国人厅发(2006)164号] 山西省自然科学基金[2008011082-1] 山西省回国留学人员科研基金[2007-50]
关键词 多发性硬化 他汀类药物 自身免疫性脑脊髓炎 multiple sclerosis statins EAE
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  • 1Stanislaus R, Gilg AG, Singh AK. et al. Immunomodulation of experimental autoimmune encephalomyelitis in the Lewisrats by Lovastatin[J]. Neurosei Lett, 2002, 333(3): 167-170.
  • 2Youssef S, Stuve O, Patarroyo JC, et al. The HMG CoA reductase inhibitor, atorvastatin, promotes a Th 2 bias and reverses paralysis in central nervous system autoimmune disease[J]. Nature, 2002, 420(6 911): 78-84.
  • 3Aktas O, Waiczies S, Smorodchenko A, et al. Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin [J]. J Exp Med, 2003, 197(6): 725-733.
  • 4Sena A, Pedrosa R, Grace M. Therapeutic potential of lovastatin in multiple sclerosis[J]. J Neurol, 2003, 250(6): 754-755.
  • 5Vollmer T, Key L, Durkalski V. Oral simvastatin treatment in relapsing remitting multiple sclerosis[J]. Lancet, 2004, 363(9 421): 1 607-1 608.
  • 6Stuve O, Prod homme T, Slavin A, et al. Statins and their potential targets in multiple sclerosis therapy[J]. Expert Opin Ther Tragets, 2003, 7(5): 613-622.
  • 7Zeinstra E, Wilczak N, Chesik D, et al. Simvastatin inhibits interferon gamma- induced MHC class Ⅱ up-regulation in cultured astrocytes[J]. J Neuroinflammation, 2006, 3: 16.
  • 8Liao JK. Isoprenoids as mediators of the biological effects of statins[J]. J Clin Invest, 2002, 110(3): 285-288.
  • 9Neuhaus O, StrasserFuchs S, Fazekas F, et al. Statins as im munomodulators: comparison with interferonbeta lb in MS[J]. Neurology, 2002, 59(7): 990-997.
  • 10Peng X, Jin J, Giri S, et al. Immunomodulatory effects of 3-hydroxy- 3-methylglutaryl coenzyme-A reductase inhibitors, potential therapy for relapsing remitting multiple sclerosis[J]. J Neuroimmunol, 2006, 178(1-2): 130-139.

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