脑梗死患者血清同型半胱氨酸水平分析

Analysis of Serum Homocystein Levels in Patients with Cerebral Infarction

目的观察脑梗死患者血清同型半胱氨酸(homocysteine Hcy)水平的变化,探讨与脑梗死严重程度的关系.方法测定68例脑梗死患者和64例健康对照者的血清Hcy含量,并分析其与脑梗死患者临床神经功能缺损程度评分的相关性.结果脑梗死患者血清Hcy水平明显高于健康组(p<0.01).脑梗死不同临床分型组间血清Hcy水平两两比较,Hcy差异无统计学意义(p>0.05).结论血清Hcy水平增高与脑梗死的发生有密切关系,可能并不能很好地反映脑梗死病变的程度,其升高仅是动脉粥样硬化的危险因素之一.

Objective To observe the regularity of fluctuation serum homocysteine （Hcy） levels in patients with cerebral infarction and to investigate the relationships Hcy and pathogenetic condition of cerebral infarction. Methods The serum levels of Hcy were measured in 68 patients with cerebral infarction and 64 healthy controls, and the correlation with the scale of clinical neurologic deficit were analyzed. Results The levels of serum Hcy in patient with cerebral infarction were significantly higher than that in healthy controls （p〈0.01）. There was no significant difference of serum Hcy level among difference clinical subtype groups of cerebral infarction （p〉0.05）. Conclusions High levels of serum Hcy is highly associated with the occurrence of cerebral infarction, Maybe high levels of serum Hcy can＇t perfectly reflect the pathological changes of cerebral infarction. The factor is one of risks of arteriosclerosis