北京和广州高脂血症及正常人群中血脂及载脂蛋白的比较

Comparison of Serum Lipids andApolipoproteins between the Hyperlipi-demic and Healthy Residents in Beijingand Guangzhou

根据近２０年的流行病学调查结果提示，通过比较北京和广州人群的血脂成分，来了解两地区人群血脂组成的差异，为两地区心血管疾病不同发病率的原因寻找线索。自北京和广州现场采集高脂血症及对照人群的血清样本，以酶法或免疫透射比浊法测定，总胆固醇、甘油三酯、高密度脂蛋白胆固醇（ＨＤＬＣ）、ＨＤＬ２Ｃ、ＨＤＬ３Ｃ、低密度脂蛋白胆固醇（ＬＤＬＣ）、载脂蛋白ＡＩ、ＡⅥ及Ｂ，并分组进行统计学显著性测验。结果发现两地区的高脂血症患者都以高甘油三酯血症为主，高脂血症组的ＨＤＬＣ水平显著低于对照组，尤以ＨＤＬＣ亚类水平低。高脂血症组载脂蛋白Ｂ和ＡⅥ高于对照组，而载脂蛋白ＡＩ无差异。

ABSTRACTAim The serum lipids and apolipoproteins betweenthe hyperlipidemic and healthy residents in Beijing andGuangzhou were studied in order to find out the clue ofhigher incidence of cardiovascular diseases in Beijingthan that in the Guangzhou area.Methods Serum samples of 336 males (168 hyper-lipidemic cases and 168 healthy controls ) from Beijingsurvey field and 388 male subjects ( 194 hyperlipidemicand 194 healthy controls) from Guangzhou field werecollected respectively for the assays of total cholestetol(TC ), triglycerides (TG ) , high density lipoproteincholesterol (HDLC ) , HDL3-C, low density lipoproteincholesterol (LDLC) (by enzyme methods ) , apolipopro-teins B, AI (by immunoturbidimetric assay) and A Ⅵ(by ELISA).Results Most of the hyperlipidemic cases were hy-pertriglyceridemia in both areas. TC, apolipoprotein A Ⅵ were higher, but HDLC, mainly HDL2C weremarkedly lower in cases of the hyperlipidemic than thatof the healthy control groups. There was no differ-ence seen about the apolipoprotein AI level betweenthe hyperlipidemic and control groups , anyhow, on theother hand, the TC, apolipoprotein B, HDLC andapolipoprotein A I of the hyperlipidemic subjects weresignificantly lower in Beijing than that in Guangzhou ,and similar results were obtained in the healthy controlgroups in both areas.Conclusion High triglycerides and low HDL levelpredominated in the serum lipids of the hyperlipidemicsubjects in both Beijing and Guangzhou areas. Theimportant point is that the serum HDL and apolipopro-tein A I levels were significantly lower in the residentsof Beijing which may contribute to the higher incidenceof coronary heart disease in Beijing than in theGuangzhou area.KEY WORDS Hyperlipidemia; Triglycerides;Apolipoproteins; Atherosclerosis