临界性高血压与颈动脉粥样硬化及相关因素分析

Borderline Hypertension , CarotidAtherosclerosis and Related Risk Fac-tors

为探讨临界性高血压患者靶器官动脉粥样硬化情况，经超声检测４８例无合并症的临界性高血压患者，与３８例正常人作对照。结果发现，临界性高血压组颈动脉内中膜厚度和动脉粥样硬化指数均明显高于对照组。逐步回归分析发现：年龄、体重指数、吸烟、高密度脂蛋白胆固醇、总胆固醇、氧化型低密度脂蛋白及病程均与颈动脉粥样硬化密切相关。由此提示，临界性高血压已成为动脉粥样硬化的重要因素，亦应尽早治疗。

ABSTRACTTo investigate atherosclerosis in patients with border-line hypertension, 48 borderline hypertensive subjectswithout complications were compared with 38 healthycontrols. The results showed that the carotid thick-ness of tunica intima and media , and atherosclerotic in-dex in patients were significantly higher than that ofcontrols. The analysis of regression revealed thatcarotid atherosclerosis was closely associated with age ,body weight index, smoking, HDL cholesterol, totalcholesterol , oxidized LDL cholesterol and the status ofhypertension. This suggests that borderline hyper-tension could be a important risk factor for atheroscle-rosis and should be treated as early as possible.KEY WORDS Borderline hypertension; CarotidAtherosclerosis ;