乳腺癌术后抑郁发生率及相关危险因素研究

Depressive symptoms and risk factors in post-surgery women with breast cancer

目的调查乳腺癌术后患者抑郁的发生状况及相关危险因素。方法应用Beck抑郁量表(BDI)对243例连续入组的乳腺癌术后患者进行抑郁评估,并记录患者的一般资料和乳腺癌的临床资料。结果以BDI总分4/5为界,92例(37.9%)乳腺癌术后患者存在有明显的抑郁症状,抑郁组的年龄、月收入显著低于非抑郁组(t=-2.306,P=0.022;χ2=7.767,P=0.021),而手术方式、术后时间、临床肿瘤分期、是否伴随其他躯体疾病、何种治疗方式、ER受体情况在抑郁组和非抑郁组间未发现显著性的差异。结论乳腺癌术后抑郁的发生比例较高,低龄、低收入可能是乳腺癌术后抑郁发生的危险因素。

Objective： The study aimed to assess the depressive symptoms and risk factors of depression in post- surgery women for breast cancer. Methods： 243 breast cancer women were consecutively recruited and assessed by instruments of self - designed questionnaire and Beck Depression Scale （BDI）. Results： Using 4/5 as cut - off score for BDI , 92 breast cancer patients （ 37.9% ） had depressive symptoms. The age and income are significantly lower in depressive group than controls （ t = - 2.3 0 6, P = 0.0 2 2 ;Х^2 = 7. 767 ,P = 0.021 ）,but there was no significant difference between depressive and non- depressive groups on time after surgery, treatment, cancer stage, estrogen receptor state and co morbidity. Conclusion： The occurrence rate of depressive symptoms in post - surgery women for breast cancer was high, younger age and lower income were the risk factors for post - surgery depression in women for breast cancer.