摘要
Several 7-alkynyl camptothecin derivatives were prepared via Sonogashira coupling. And anti-tumor activities of these compounds were evaluated against human esophageal cancer cell line (Eca-109), human chronic myeloid leukaemia cell line (K562), bladder cancer cell line (5637) and gastric cell line (SGC7901). Compounds 9a--d and 10a exhibited remarkable in vitro cytotoxic activity, compared with topotecan.
Several 7-alkynyl camptothecin derivatives were prepared via Sonogashira coupling. And anti-tumor activities of these compounds were evaluated against human esophageal cancer cell line (Eca-109), human chronic myeloid leukaemia cell line (K562), bladder cancer cell line (5637) and gastric cell line (SGC7901). Compounds 9a--d and 10a exhibited remarkable in vitro cytotoxic activity, compared with topotecan.
基金
the financial support by Program for New Century Excellent Talents in University.