摘要
Several 7-alkynyl camptothecin derivatives were prepared via Sonogashira coupling. And anti-tumor activities of these compounds were evaluated against human esophageal cancer cell line （Eca-109）, human chronic myeloid leukaemia cell line （K562）, bladder cancer cell line （5637） and gastric cell line （SGC7901）. Compounds 9a--d and 10a exhibited remarkable in vitro cytotoxic activity, compared with topotecan.
Several 7-alkynyl camptothecin derivatives were prepared via Sonogashira coupling. And anti-tumor activities of these compounds were evaluated against human esophageal cancer cell line （Eca-109）, human chronic myeloid leukaemia cell line （K562）, bladder cancer cell line （5637） and gastric cell line （SGC7901）. Compounds 9a--d and 10a exhibited remarkable in vitro cytotoxic activity, compared with topotecan.
基金
the financial support by Program for New Century Excellent Talents in University.
