高脂血症家族遗传因素、超重对血脂水平的影响及其协同作用的研究

Genetic Factors of Hyperlipidemia, Overweight and Their Synergism to the Level of Serum Lipids

目的探讨遗传因素、超重及其相互作用对血脂水平的影响。方法采用家系调查法，于１９９６～１９９７年在北京地区搜集家族性高脂血症（混合型高脂血症家系和家族性高胆固醇血症家系）及正常对照家系共２５个进行统计分析。结果高脂血症家系血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平显著高于正常对照家系；调整其他危险因素后的血脂水平，高脂血症家系超重组＞高脂血症家系非超重组＞对照家系超重组＞对照家系非超重组。结论家族遗传因素和超重都是高脂血症重要的危险因素，二者具有协同作用。

Aim To determine the contribution of body mass index(BMI) and family genetic factors(FGFs) to the development of hyperlipidemia and the interaction of these two factors. Methods 25 pedigrees with familial hyperlipidemia[familial combined hyperlipidemia(FCHL) and familial hypercholesterolemia(FH)] and control families were investigated and analysed in Beijing area during 1996￣1997. Results There are significantly higher levels of total cholesterol(TC),triglycide(TG),low density lipoprotein cholesterol(LDLC) in hyperlipidemia families than that of control families. After adjustment of other risk factors,the serum levels of TC,TG,LDLC from high to low is: overweight in hyperlipidemia families,nonoverweight in hyperlipidemia families, overweight in control families and nonoverweight in control families. Conclusion These findinds suggest that FGFs and BMI are both important risk factors for hyperlipidemia . They influence on serum lipid synergically.