HBcAg在隐匿性乙型肝炎中的临床意义

Analysis of HBcAg in Occult Hepatitis B Virus Infection and Its Clinical Significance

【目的】探讨HBcAg与HBVDNA水平及乙肝病毒标志物模式之间的关系，为临床提供隐匿性乙型肝炎病毒传染性及诊断的实验室依据。【方法】用放射免疫法检测1053例HBsAg阴性标本的六种血清标志物，同时对其中107例标本用聚合酶链反应（PCR）法检测HBVDNA。【结果】1053例HbsAg阴性中HBcAg阳性率为7．31％。在同时检测HBcAg和HBVDNA的107例各种感染模式中．HBcAg阳性率为10．28％，HBVDNA阳性率为8．65％，且阳性率相似，差异无统计学意义（P〉0．05）。HBVDNA含量均低于10^4Copies／mL。[结论]HBcAg可反映HBV病毒感染与复制，是乙型肝炎早期诊断的可靠指标。HBcAg检测作为HBV血清学方法的补充．对乙型肝炎的临床诊断具有重要意义。

[Objective] To explore the relationship between quantitative HBcAg and hepatitis B virus DNA level. HBV markers （HBV-M） so as to provide the laboratory basis for predicting the infectivity and diagnosis of occult hapatitis B in clinical practice. [Methods] Six serological markers of 1053 samples with negative HBsAg were detee ted by radioimmunoassay, meanwhile HBVDNA of 107 samples was tested by polymerase chain reaetion（PCR）. [Results]In 1053 samples witb negative HBsAg , the positive rate of HBcAg antigen was 7.31%. The positive rate of HBcAg antigen and HBVDNA was identical in 107 cases of different infections detected at the same. There was no significant difference （p〉0.05）. The positive rate of HBcAg antigen and HBVDNA was 10.28% and 8. 65%. respectively. The content of HBVDNA was less than 104 copies/ml. [Conclusion] HBcAg antigen may reflecr the rep-lication and infection of hepatitis B virus, which can be used as a reliable marker of early diagnosis in hepatitis B, and has important significance in clinic. HBcAg has the important clinical value as a supplement of serological methods for the diagnosis of hepatitis B.