马普替林与氯丙咪嗪治疗抑郁症对照研究

A study on maprotylln in the treatment of depression in comparison with clomipramine

目的 评价马普替林对抑郁症的疗效。方法 采用国产马普替林与氯丙咪嗪随机双盲对照治疗60例抑郁症。以HAMD、CGI及TESS评定症状、疗效和副反应。结果 二者的疗效相当,马普替林抗抑郁作用出现较早,副反应少且轻。结论 马普替林是一种安全、快速、有效的抗抑郁剂。

Objective: To evaluate the efficacy of maprotyline in the treatment of depression. Methods: Sixty inpatients with major depression who met with CCMD-2-R diagnostic criteria were randomly treated with maprotyline or clomipramine for 6 weeks, and HAMD > CGI, and TESS were assessed in order to evaluate their efficacy and safety. Results: The efficacy of maprotyline (response rate 76. 7%) was similar to ciomipramine (80%) in the treatment of depression, p>0. 05, and its side effects were significantly fewer than clomipramine, p<0. 05. Conclusion: Maprotyline is a safe and useful drug for the treatment of major depression.