胶质瘤前列腺素水平与瘤周水肿的关系

Glioma prostaglandin levels correlate with brain edema

应用放射免疫技术和影像学方法测定了30例不同类型胶质瘤的PG水平和瘤周水肿程度。结果二组恶性胶质瘤的TXB_2水平和TXB_2/6-Keto-PGF1a。比值显著升高。三组水肿级别之间，TXB_2水平和TXB2/6-Keto-PGF1a比值具有显著性差异（P＜0.01）。TXB2水平和TYXB2／6－Keto－PGF1a比值与瘤组织含水量呈显著性正相关（r1＝0．53，r2＝0．72，P＜0.01）。提示胶质瘤组织PG的代谢呈紊乱状态。而PGI2和TXA2的代谢失衡可能是影响瘤周水肿形成的因素之一。

The present study was designed to prospectively investigated the PG levels and extent of peritumoral edema in 30 case of gliomas by using methods of Radioirnmunoassay and Imaging. Both TAB_2 and 6-Keto-PGF1a levels in malignant glioma groups makedly go up over that in tile control group. Difference in TXB_2 level and TXB_2/6-Keto-PGF1a raio between three edema grades were statistically signifficant. TXB_2 level and ratio of TXB_2/6-Keto-PGF1a were close correlated with water concen tration(r1 =0.53. r2=0. 72, P<0.01 ). our findings suggested that the metabolism of PG in glioma were in the state of disorder. and that the imbalance between PGI12 and TXA2 may be one of factors which affect the formation of peritumoral edema.