摘要
目的：分析目前国际上有关粘细菌微生物类群产生生物活性物质的研究进展，为在我国开展粘细菌资源的利用提供参考。方法：在对粘细菌产生生物活性物质的特点全面分析的基础上，按生物活性物质的作用机制进行分析讨论。结果：从近２０年的研究结果看，粘细菌不但产生非常丰富的次级代谢产物，而且产物具有结构新，种类多，产生菌比率高，作用机制多样等特点。但由于早期粘细菌研究操作的困难，开展有关工作的实验室很少，目前几乎无商业化产品，但已有些活性物质如ｅｐｏｔｈｉｌｏｎｓ引起医药界的广泛注视。结论：粘细菌是新型生物活性物质筛选的优良资源。
OBJECTIVE:In order to enhance myxobacterial studies, the progresses in this field were reviewed. METHODS:The myxobacterial bioactive substances were discussed in accordance with their mechanisms. RESULTS: Significant progresses in myxobacterial studies have been achieved in last 20 years but only a few laboratories deal on these studies and now there was no commercial products available. However, some active materials obtained such as epothilons, attracts attentions in the pharmaceutical field. CONCLUSION: Myxobacteria is a potential source for selection of bioactive substances.
出处
《中国新药杂志》
CAS
CSCD
1998年第2期84-89,共6页
Chinese Journal of New Drugs
基金
国家自然科学基金
