摘要
目的:观察小半夏加茯苓汤对小鼠的急性毒性实验和了解毒靶器官。方法:以最大浓度药液灌胃给药,24h内给药3次,连续观察7天。详细观察记录小鼠行为活动、状态、饮食、大便、小便、毛色、分泌物及死亡等情况。结果:全部动物健存,也无明显中毒反应,测得小半夏加茯苓汤最大受试药物量为267.60grawdrug·kg-1,为临床患者拟用量的382.29倍。结论:小半夏加茯苓汤对小鼠无明显急性毒性反应。
Objective:To observe the acute toxicity test of Xiao Banxia plus fuling decoction.Methods:We fed the mice with the maximum administration concentration drug for 7 days,and gavage administration was done for three times within 24h. Then,we observed the action,state,diet,stool,piss,hair color,secretion and death amount of the mice.Results:All the mice were healthy and had no markedly poisoning reaction. The maximum administration dosage of Xiao Banxia plus fuling decoction was 267.60g raw drug·kg-1,equivalent to patient's daily administration dosage by 382.29 times.Conclusion:Xiao Banxia plus fuling decoction has no markedly acute reaction.
出处
《辽宁中医药大学学报》
CAS
2009年第5期200-201,共2页
Journal of Liaoning University of Traditional Chinese Medicine
基金
贵阳中医学院2007-2008年度大学生科研基金课题(200711)
关键词
小半夏加茯苓汤
急性毒性
灌胃给药
小鼠
Xiao Banxia plus fuling decoction
acute toxicity
gavage administration
mouse