小半夏加茯苓汤的急性毒性研究

Acute Toxicity Test of Xiao Banxia Plus Fuling Decoction on Mouse

目的:观察小半夏加茯苓汤对小鼠的急性毒性实验和了解毒靶器官。方法:以最大浓度药液灌胃给药,24h内给药3次,连续观察7天。详细观察记录小鼠行为活动、状态、饮食、大便、小便、毛色、分泌物及死亡等情况。结果:全部动物健存,也无明显中毒反应,测得小半夏加茯苓汤最大受试药物量为267.60grawdrug·kg-1,为临床患者拟用量的382.29倍。结论:小半夏加茯苓汤对小鼠无明显急性毒性反应。

Objective：To observe the acute toxicity test of Xiao Banxia plus fuling decoction.Methods：We fed the mice with the maximum administration concentration drug for 7 days,and gavage administration was done for three times within 24h. Then,we observed the action,state,diet,stool,piss,hair color,secretion and death amount of the mice.Results：All the mice were healthy and had no markedly poisoning reaction. The maximum administration dosage of Xiao Banxia plus fuling decoction was 267.60g raw drug·kg-1,equivalent to patient＇s daily administration dosage by 382.29 times.Conclusion：Xiao Banxia plus fuling decoction has no markedly acute reaction.