73例抗生素相关性腹泻的临床分析

Analysis of 73 cases of antibiotic-associated diarrhea

目的分析抗生素相关性腹泻(antibiotic associated-diarrhea,AAD)的发病机制、临床表现、辅助检查及治疗方法。方法对我院2006年10月至2007年10月收治的73例AAD患者的临床资料进行回顾性分析。结果所有患者均出现腹泻,每日3～20次,以水样便、糊状便为主。单纯腹泻型所占比例最高(69.86%),结肠炎型次之(19.81)。β-内酰胺类药物腹泻发生率最高,占60.15%,喹诺酮类次之,占16.56%。结论使用抗生素中出现的腹泻要考虑到AAD的可能,需进行粪涂片、粪培养等检查,应停用相关的抗生素,尽早处理。

Objective To explore the pathogenesis, clinical features, assisted examinations and treatment of antibiotic-associated diarrhea （AAD）. Methods Seventy-three patients with antibiotic-associated diarrhea at Beijing Haidian Hospital in recent one year were retrospectively studied. Results All the seventy-three patients developed AAD, the frequency of diarrhea was from three to more than twenty per day. β-lactam antibiotics was the most common one（60.15%）, quinolones was the next one（16.56%）. Conclusions AAD should be taken into account when patients using antibiotics developed diarrhea. At the same time the patients should be performed stool cultivation and smear examination, stop to use correlated antibiotic and treated as early as possible.