血清肿瘤相关抗原(MG_7-Ag)与胃癌关系的研究

Study on Relationship Between the Serum Tumor Associated Antigen (MG_7- Ag) and Gastric Cancer

应用一步法免疫放射分析技术对157例次胃癌、胃粘膜异型增生、肠化和正常人进行了血清抗低分化胃癌单克隆抗体MG相应抗原(MG_7-Ag)含量的研究.3组病人及正常人血清MG_7Ag平均含量分别为36.52U/ml、5.28 U/ml、3.30 U/ml和1.88 U/ml.胃癌组阳性率明显高于其他3组(P<0.01),胃粘膜肠化组和异型增生组明显高于正常组(P<0.01),提示胃内的这两种特殊组织改变可能是癌变的前驱特征.对19例进展期胃癌术前检测血清MG_7-Ag,阳性率为57.89%,术后无复发组阳性率为7.69%(P<0.01),术后复发组阳性率为50.0%,与术前相比,P>0.05.说明随着肿瘤在人体的去除,MG_7-Ag可以相应下降,而当肿瘤重新出现时,其含量随之上升.利用这个规律,可以用MG7_7-Ag判断胃癌患者手术或化疗效果,估计预后,指导诊断和治疗.

In this article, the levels of monoclonal antibody MG7 tumor associated antigen(MG7-Ag) of anti-low differentiated gastric cancer were determined in 157 cases which were divided into 4 groups(gastric cancer, dysplasia, intestinal metaplasia and normal) . The results showed that the mean level of serum MG7-Ag in these groups was 36. 52 U/ml, 5.28 U/ml, 3.30 U/ml and 1.88 U/ml respectively. The MG7-Ag positive rates of the dysplasea and metaplasia groups were higher than that of normal group. It suggested a potential danger of cancerous changes. The positive rate of MG7-Ag in 19 patients of advanced gastric cancer before operation was 57. 89% . The positive rate in the nonrecurrent cases after operation was lower than that in which before operation (P< 0.01). The similar positive rate was found( P>0.05)) in the recurrent patients after operation and before operation. These findings suggested that the changes of the serum MG7-Ag was available to assess the effects of treatment and predict the prognosis in patients with gastric cancer.