青少年肥胖及代谢异常与INSIG2基因多态性

Relation between INSIG2 gene polymorphism and obesity,metabolic abnormailities in children and adolescents

目的研究胰岛素诱导基因2（INSIG2）rs7566605多态性与我国儿童青少年肥胖和代谢异常的相关性。方法在北京市海淀区选择1 103名7～18岁儿童青少年进行身体和代谢指标测量,并进行rs7566605多态性的基因型鉴定。结果1 103名儿童青少年rs7566605的突变率（G〉C）为35.56%～37.06%,与欧美人群接近。体重正常、超重和肥胖组基因型及等位基因频率差异无统计学意义（P〉0.05）。分层分析发现,超重组CC基因型携带者的皮褶厚度和体脂百分比高于GG/GC基因型者（P〈0.05）;肥胖组CC基因型携带者的甘油三酯（TG）平均比GG/GC基因型者高0.21 mmol/L（P=0.014）。结论ISNIG2基因rs7566605多态性与我国儿童超重或肥胖的发生无相关性,但是该多态性对超重和肥胖儿童青少年体脂含量及TG蓄积可能有一定影响。

Objective To test the association of insulin induced gene 2（INSIG2） rs7566605 polymprphism with obesity and the metabolic abnormalities in children and adolescents in China. Methods Orera/1 1 103 students aged 7 to 18-year- old were sellected in Haidian district, Beijing. The body and metabolic indexes were measured and the rs7566605 polymorohism was genotyped. Results The mutation rate of rs7566605 （G 〉 C） in the children and adolescents was 35.56% to 37.06% ,similar to those of European and the United States population. The differences of genotype and allele frequencies in normal weight,overweight and obese group were not significant （P 〉 0. 05 ）. Stratified analyses showed that the CC genotype carriers in overweight group had higher skinfold thickness and body fat percentage than that of GG/GC genotype （ P 〈 0.05 ）. Average level of triglyceride （TG） of CC genotype carriers was 0. 21mmol/L and higher than that of GG/GC genotype in obese group （ P = 0. 014）. Conclusion There was no association between INSIG2 gene rs7566605 polymorghism and childhood overweight or obesity in China. But the polymorphism may have some influence on TG accumulation and body fat content in overweight or obese children and adolescents in China.