不同民族居民血尿酸水平与心血管病指标关系

Serum uric acid level and related indicators of cardiovasular disease in Han and Uygur nationality

目的探讨汉族与维吾尔族血尿酸水平与心血管病相关指标之间的关系。方法对2006年1～12月收集的498名不同民族居民血样本进行尿酸及其他生化指标检测,采用SPSS软件进行方差分析、χ^2检验。结果随着血尿酸（SUA）水平的升高,汉族和维吾尔族除了高密度脂蛋白（HDL-C）降低,其他指标均有升高的趋势,统计学检验除血糖（FBS）外其他指标差异均有统计学意义（P〈0.05）。相关分析发现,汉族血尿酸与FBS无相关,与HDL-C呈负相关（r=10.271,P〈0.01）,与其他生理、生化指标均呈正相关;而维吾尔族血尿酸与FBS和HDL-C无关外,其他生理、生化指标均呈正相关。汉族和维吾尔族肥胖、高血压、高血糖、高甘油三酯血症、高胆固醇血症、混合型高脂血症和低高密度脂蛋白血症的检出率均随着SUA水平的增高而升高,统计学检验汉族不同尿酸组之间肥胖、高血压、高甘油三酯血症、代谢综合征检出率差异有统计学意义（P〈0.05）。维吾尔族除了高血糖的检出率各尿酸组之间差异无统计学意义（P〉0.05）外,其他指标各尿酸水平组代谢性疾病检出率差异均有统计学意义（P〈0.05）。结论汉族和维吾尔族血尿酸水平与除血糖外的心血管病相关指标密切相关,并且对各代谢紊乱的发生起促进作用。因此,预防和治疗高尿酸血症对减少心血管病发生和发展将有积极作用。

Objective To fred the correlation of plasma uric acid levels and the related indicators of candiovascular disease in Han and Uygur nationality in Xinjiang. Methods The blood samples of 498 subjects aged 20 to 70 years were collected from January to May 2006 in Urumchi and analyzed for uric acid （ SUA）, glycerin, total cholesterol, high density lipoprotein, low density lipoprotein. One-way analysis of variance was used to analyze data from people with different levels of serum uric acid. Results Except the fasting blood glucose （ FBS ）, all biochemical indexes were increased in Han and Uygur nationality, but HDL-C showed a decresed trend （ P 〈 0. 05）. Except there was a low negative correlation between uric acid and HDL-C（ r = 0. 271 ） ,FBS and other biochemical indicators showed positive correlation with uric acid in Han nationality. The prevalence of obesity, hypertension, diabetes mellitus, hypertriglyceridemia, hypercholesterolemia, and metabolic syndyome showed a increasing trend with the SUA level increase（ P 〈 0. 05 ）. The prevalences of obesity and hypertriglyceridemia in Han people and all other diseases in the Uygur ethnic, except the diabetes mellitus, showed significant differences between groups of subjects with different SUA levels. Conclusion Except FBS, the serum uric acid level has same effects on cardiovascular disease indicators among Han and Uygur nationalities. SUA plays a role in the development of cardiovascular disease in the general population.