赣榆县农村少年儿童幽门螺杆菌感染状况调查

Investigation on helicobacter pylori infection in rural children in Ganyu county

目的了解江苏省赣榆县农村地区6～15岁儿童幽门螺杆菌（Helicobacter pylori,Hp）感染状况及其危险因素。方法2004年12月,对江苏省赣榆县农村地区8 161名学生进行幽门螺杆菌感染状况调查,通过筛查建立新增感染率调查队列人群,应用13C尿素呼气试验和血清幽门螺杆菌抗体检测进行定期随访。结果基线调查显示,调查对象的平均感染率为20.16%,其中男性、女性分别为18.78%,22.22%;6岁～、7岁～、8岁～、9岁～、10岁～、11岁～、12～15岁年龄组的感染率分别为15.02%,17.37%,19.33%,19.43%,18.86%,24.40%,23.64%。单因素分析和多因素条件Logistics回归分析结果显示,年龄、性别、学校性质、乡镇经济水平与发病有关。通过为期1年的队列随访,平均发病密度为2.32%,男性、女性分别为2.01%,2.80%。6岁～、7岁～、8岁～、9岁～、10岁～、11岁～、12～15岁年龄组的发病密度分别为2.68%,2.40%,1.99%,2.06%,1.31%,2.91%,5.00%。单因素分析显示,性别、年龄、学校性质以及乡镇经济水平与新发病例均无关。结论江苏省赣榆县农村地区6～15岁儿童存在较高的幽门螺杆菌感染率,呈逐龄不匀速的递增现象,但低于国内其他地区。

Objective To understand the incidence and risk factors of helicobacter pylori（Hp） infection among rural children in Ganyu county of Jiangsu province. Methods Hp infection survey was carried out in pupils in Ganyu county in Dec. 2004, and a cohort of Hp infection was built by detecting lip rapid urease and anti-Hp antibody. Results The total rate of Hp infection was 20. 16% ,and the rate of boys and girls was 18. 78% ,22. 22% ,respectively. The infection rate among the subjects of 6,7,8,9,10,11 years old and between 12 to 15 years old was 15.02%, 17.37%, 19.33%, 19.43%, 18. 86% ,24. 40% ,23.64%, respectively. By using logistic regrssion we found that age, sex, school, economy level had remarkable correlation with infection rate. The cohort research showed that the total incidence density was 2. 32%, and that of the boys and girls was 2. 01% ,2. 80%, respectively. The incidence density among the pupils of 6,7,8,9,10,11 years old and between 12 to 15 years old was 2. 68% ,2. 40%, 1.99% ,2. 06%, 1.31% ,2.91% ,5.00% ,respectively. By using univariate logistic regrssion we found that age, sex, school, economy level had no correlation with incidence density. Conclusion The infection rate of Hp in rural children in Ganyu county of Jiangsu province was high, which showed an un-fixed ascending trend with age growth, but the infection rate was lower than that of other areas.