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α-干扰素肿瘤抗性相关分子标志物的研究进展 被引量：2

Advance in research of tumor molecular markers related to IFN-α resistance
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摘要 α-干扰素(interferon-α,IFN-α)是一种重要的治疗性细胞因子,通过调节细胞周期、抑制原癌基因、调控细胞黏附和血管生成等机制发挥抗肿瘤效应。然而患者对IFN-α反应性的差异限制了其在临床的广泛使用。信号转导通路中一些关键因子如STAT1、STAT3、P48、SOCS1等的异常表达,与肿瘤的IFN-α抗性机制相关;某些原癌基因Bcl-2、c-myc、EVI-1等的过度表达也参与IFN-α抗性形成;此外DNA甲基转移酶、组蛋白修饰与肿瘤IFN-α抗性的发生密切相关。因此,对这些预测IFN-α临床疗效有潜在价值的分子标志物进行多因素分析,选择适合IFN-α治疗的敏感病例,设计个体化的治疗方案,将成为今后肿瘤治疗的一个发展方向。
作者 荆妮 吕秋军
机构地区 杰华生物技术(北京)有限公司
出处 《中国肿瘤生物治疗杂志》 CAS CSCD 北大核心 2009年第2期203-206,共4页 Chinese Journal of Cancer Biotherapy
关键词 Α-干扰素 肿瘤分子标志物 JAK-STAT 表观遗传学 原癌基因
分类号 R730.54 [医药卫生—肿瘤] R392.11 [医药卫生—免疫学]
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参考文献32

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同被引文献18

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中国肿瘤生物治疗杂志
2009年 第2期

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