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黑素瘤免疫治疗的研究进展 被引量：2

Advance in immunotherapy of melanoma
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摘要 黑素瘤是起源于黑素细胞或其母细胞的恶性肿瘤,对放化疗不敏感,一旦远处转移,难以控制,预后极差。黑素瘤因存在很强的免疫源性,一直是生物治疗的研究热点。以往研究发现,LAK、TIL等过继性细胞以及黑素瘤抗原相关免疫瘤苗等都有一定的治疗效果。近年来随着免疫编辑学说的提出,新一代肿瘤免疫治疗方案,如抗CTLA-4抗体、针对肿瘤抗原的IgG抗体、Toll样受体9激动剂、白喉毒素/IL-2融合蛋白等开展了一系列临床试验,并取得了可喜的进步。
作者 张新伟 任秀宝
机构地区 天津医科大学附属肿瘤医院生物治疗科
出处 《中国肿瘤生物治疗杂志》 CAS CSCD 北大核心 2009年第2期207-210,共4页 Chinese Journal of Cancer Biotherapy
基金 国家自然科学基金资助项目(No.30801339)~~
关键词 黑素瘤 免疫治疗 编辑学说 CTLA-4 过继性细胞治疗
分类号 R730.5 [医药卫生—肿瘤]
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参考文献25

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同被引文献49

  • 1白爱民,贾艳敏,张晓菁.siRNA为基础的RNAi在肿瘤基因治疗中的应用进展[J].中华肿瘤防治杂志,2007,14(12):953-955. 被引量：16
  • 2Hocker TL,Singh MK,Tsao H.Melanoma genetics and therapeutic approaches in the 21st century:moving from the benchside to the bedside[J].J Invest Dermatol,2008,128(11):2575-2595.
  • 3O′Connell MP,Fiori JL,Xu M,et al.The orphan tyrosine kinase receptor,ROR2,mediates Wnt5A signaling in metastatic melanoma[J].Oncogene,2010,29(1):34-44.
  • 4Singh S,Sadanandam A,Varney ML,et al.Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion[J].Int J Cancer,2010,126(2):328-336.
  • 5Filipowicz W,Bhattacharyya SN,Sonenberg N,et al.Mechanisms of post-transcriptional regulation by microRNAs:are the answers in sight?[J].Nat Rev Genet,2008,9(2):102-114.
  • 6Mueller DW,Bosserhoff AK.Role of miRNAs in the progression of malignant melanoma[J].Br J Cancer,2009,101(4):551-556.
  • 7Zheng JN,Pei DS,Mao LJ,et al.Oncolytic adenovirus expressing interleukin-18 induces significant antitumor effects against melanoma in mice through inhibition of angiogenesis[J].Cancer Gene Ther,2010,17(1):28-36.
  • 8Jiang G,Liu YQ,Wei ZP,et al.Enhanced anti-tumor activity by the combination of a conditionally replicating adenovirus mediated interleukin-24 and dacarbazin e against melanoma cells via induction of apoptosis[J].Cancer Lett,2010,294(2):220-228.
  • 9Zheng JN,Pei DS,Sun FH,et al.Inhibition of renal cancer cell growth by oncolytic adenovirus armed short hairpin RNA targeting hTERT gene[J].Cancer Biol Ther,2009,8(1):84-91.
  • 10Singh R,Paterson Y.Immunoediting sculpts tumor epitopes during immunotherapy[J].Cancer Res,2007,67(5):1887-1892.

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中国肿瘤生物治疗杂志
2009年 第2期

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