沉默信息调节因子2相关酶1的研究进展

Research Advancement of Sirtuins1

沉默信息调节因子2相关酶1（SIRT1）是一种NAD＋依赖的组蛋白去乙酰化酶，与多种细胞生物学功能如基因转录沉默、细胞生长周期调节、能量代谢包括糖异生和脂质累积、胰岛素分泌、血管生成、神经保护、病毒感染以及细胞衰老等有着密切的关系。SIRT1作用于各种蛋白质如p53、核因子KB、转录激活蛋白等使其去乙酰化而调节其功能。此外，SIRT1的调节剂有可能成为治疗疾病的新靶点。

Sirtuinsl （SIRT1）is a NAD ＋ -dependent histone deacetylase, and it acts as modulators of cellular metabolism in different physiological contexts such as gene transcription silencing,cell cycle and growth regulation ,energy metabolism, insulin secretion, angiogenesis, neuroprotection, virus infection and cell ageing. SIRT1 deacetylates approximately a dozen known substrates including p53 ,nuclear factor KB ,Tat. Modulators of SIRT1 is gaining increasing importance in the development of innovative treatment strategies for cancer, neurodegenerative disorders and metabolic disease.