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PI3K-Akt信号通路与心肌保护 被引量：11

PI3K-Akt Signaling Pathway and Myocardial Protection
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摘要 越来越多的研究表明，药物及非药物手段可以在再灌注之初通过活化磷酯酰肌醇-3-激酶-丝氨酸／苏氨酸激酶（P13K-Akt）这一共同通路，发挥提高心肌功能和促进细胞存活的重要作用。本文对P13K、Akt、下游靶点、效应器在缺血／再灌注中的作用进行综述，阐明P13K-Akt信号通路的主动保护效应在心肌保护中的重要性。 More and more studies have shown that pharmacological and other strategies can activate PI3K-Akt signaling pathway which could improve myocardial function and survival. This review is to organize these findings to better understand PI3 K-Akt, its downstream targets and end effector in the ischemia reperfu- sion injury,to elucidate the importance of the prosurvival pathway PI3K-Akt signaling pathway.
作者 唐莹 刘金东
机构地区 江苏省麻醉医学研究所重点实验室
出处 《医学综述》 2009年第10期1470-1473,共4页 Medical Recapitulate
关键词 磷酯酰肌醇-3-激酶-丝氨酸/苏氨酸激酶 心肌保护 心肌缺血/再灌注损伤 PI3 K-Akt Myocardial preservation Myocardial ischemia/reperfusion injury
分类号 R614 [医药卫生—麻醉学]
  • 相关文献

参考文献40

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二级参考文献25

  • 1Jian-Sheng Xiao, Fang-Gang Cai, Ying Niu, Yi Zhang, Xian-Ling Xu and Qi-Fa Ye Wuhan, China Research Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China,Department of General Surgery, First Affiliated Hospital, Fujian Medi- cal College, Fuzhou 350005, China ,and Xiangya Medical Trans- plantation Academy of Central South University, Changsha 410013, China.Preconditioning effects on expression of proto-oncogenes c-fos and c-jun after hepatic ischemia/reperfusion in rats[J].Hepatobiliary & Pancreatic Diseases International,2005,4(2):197-202. 被引量：8
  • 2彭龙云,马虹,何建桂,高修仁,张焰,何小洪,翟原生,张雪娇.缺血后处理减轻大鼠肥厚心肌缺血再灌注损伤的观察[J].中华心血管病杂志,2006,34(8):685-689. 被引量：21
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  • 6Yang XM, PhilippS, DowneyJM, et al. Postconditioning's protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyl cyclase activation. Basic Res Cardiol, 2005, 100(1): 57-63
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  • 8Zhu M, Feng J, Lucchinetti E, et al. Ischemic postconditioning protects remodeled myocardium via the PI3K-PKB/Akt reperfusion injury salvage kinase pathway. Cardiovasc Res, 2006, 72(1): 152-62
  • 9Tillack D, Reuβner C, Ruth H, et al. Postconditioning the in vivo rat heart reduces myocardial injury through a PI3K- and mTOR-dependent pathway which involves the activation of GSK3β. J Mol Cell Cardiol, 2006, 40(6): 971
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共引文献13

同被引文献87

引证文献11

二级引证文献38

医学综述
2009年 第10期

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