高压氧与低分子肝素对改善脑梗死患者血液流变状态的实验研究

Clinical research for the hemorheological characteristic of patients with cerebral infarction who were treaded with hyperbaric oxygen or low molecular weight heparin

目的比较高压氧与低分子肝素对脑梗死患者血液流变状态的影响。方法随机选取经临床确诊的脑梗死患者66例作为治疗组,并将其按接受两种不同治疗方案分成两个不同的实验组,一组31例给予高压氧治疗,另一组35例给予低分子量肝素治疗,同时随机选取体检健康人群作为试验对照组。分别测量两治疗组治疗前和治疗后血液流变学的多项指标,并与对照组进行比较。结果治疗组血液流变学中全血高切粘度、全血低切粘度、血浆粘度和红细胞沉降率(ESR)较对照组有明显升高(P<0.05),治疗组治疗后较治疗前血液流变学多个指标(全血高切粘度、全血低切粘度、血浆粘度和ESR)均明显下降(P<0.05),但治疗组内两个实验组间各指标间无显著性差异。结论高压氧与低分子肝素治疗能明显改善脑梗死患者血液流变状态,增强抗凝聚和抗血栓作用。

Objective To investigate the hemorheological characteristic of patients with cerebral infarction who were treaded with hyperbaric oxygen or low molecular weight heparin respectively. Methods Selected 66 patients randomly who were diagnosed the cerebral infarction, divided them into two trial group, one group within 31 patients were treated with hyperbaric oxygen, the other group with 35 patients were therapied with low molecular weight heparin, routine hemonrheological tests before and after therapy were carried out in the two trial groups with 31 normal people served as control. Results The high coefficient of viscosity with whole blood, the low coefficient of viscosity with whole blood, the plasma viscosity and the erythrocyte sedimentation rate （ESR） in the two trial groups were obviously higer than comtrol group, the hemorheological index after therapy were obviously lower than before therapy, but, there were no significant difference between the two trial groups. Conclusion The hemorheology of the cerebral infracted patients after therepy using hyperbaric oxygen or low molecular weight heparin that can heighten anticoagulation and anti-thrombus can be changed, so this therapy should be widely recommended to clinical.