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首灵健脑胶囊治疗多发性梗死性痴呆30例临床研究 被引量:2

Clinical Study on Efficacy of Shouling Jiannao Capsule on Patients with Multiple Infarction Dementia:A Report of 30 Cases
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摘要 【目的】观察首灵健脑胶囊对多发性梗死性痴呆(MID)疗效及血脂、血液流变学的影响。【方法】将50例MID患者随机分为治疗组和对照组,治疗组30例给予首灵健脑胶囊(由制首乌、赤灵芝、三七、丹参、广郁金等组成)治疗;对照组20例给予喜德镇治疗。两组疗程均为2个月。分别观察两组临床疗效和治疗前后中医证候积分,长谷川痴呆量表(HDS)和简易智能表(MMSE)积分,血脂、血液流变学各项指标以及红细胞超氧化物歧化酶(SOD)、血浆脂质过氧化物(LPO)、经颅多普勒(TCD)等的变化情况。【结果】(1)临床疗效方面:总有效率治疗组、对照组分别为90.0%、55.0%,两组比较差异有显著性意义(P<0.05),说明治疗组疗效优于对照组;而且治疗组可明显改善患者的病情程度,尤其对轻、中度患者疗效达到90%以上,不同中医证型的疗效以脾肾两虚型及髓海不足型最好。(2)中医症状积分及量表积分方面:治疗后两组中医症状积分均较治疗前显著降低(P<0.01),MMSE、HDS积分较治疗前显著升高(P<0.05或P<0.01),治疗组与对照组比较差异有显著性意义(P<0.05)。(3)血脂、血液流变学各项指标以及SOD、LPO、TCD等指标方面:治疗后治疗组血脂、血液流变学以及SOD、LPO、TCD等各项指标均有显著改善(与治疗前比较,P<0.05或P<0.01),且其改善作用显著优于对照组(P<0.05)。【结论】首灵健脑胶囊在改善MID患者临床症状及实验室指标等方面疗效确切。 Objective To investigate the therapeutic effect of Shouling fiannao Capsule ( SJC ) for the treatment of multiple infarction dementia (MID) , and to observe the effect of SJC on blood lipid level and hemorrheology. Methods Fifty MID patients aged 45 -80 subjecting to the diagnostic standards were randomly divided into two groups : treatment group ( N = 30 ) received SJC ( mainly composed of Radix Polygoni Multiflori, Ganoderma Lucidum, Radix Notoginseng, Radix Salviae Mihiorrhizae and Radix Curcumae), and control group (N = 20) received dihydroergotoxine. The treatment lasted 2 months. The therapeutic effect in both groups was evaluated after treatment, and the changes of scores of TCM syndromes, Hasegava Dementia Scale (HDS) , and Minimental State Examination (MMSE) were observed before and after treatment. Meanwhile, blood lipid level, hemorheological indexes, erythrocyte superoxide dismutase (SOD), plasma lipid peroxide (LPO) and transcranial color Doppler (TCD) were examined and statistically analyzed before and after treatment in both groups. Results After treatment, the total effective rate was 90. 0% in the treatment group and 55.0% in the control group, the difference being significant ( P 〈 0. 05 ). The therapeutic effective rate on relieving TCM syndromes in the treatment group was over 90% for mild and moderate MID, and the effect was the best for the syndrome of deficiency of both spleen and kidney and for the syndrome of brain deficiency. The scores of the TCM syndromes were decreased (P 〈 0. 01 ), MMSE and HDS scores were increased (P 〈 0. 05 or P 〈 0. 01 ) after treatment in both groups as compared with those before treatment, and the differences were significant between the two group after treatment (P 〈 0. 05). Blood lipid level, hemorheological indexes, SOD, LPO and TCD were improved in both groups after treatment (P 〈 0. 05 or P 〈 0. 01 compared with those before treatment) , and the improvement in the treatment group was superior to that in the control group ( P 〈 0. 05 ). Conclusion Shouling Jiannao Capsule exerts certain effect for MID through relieving symptoms and improving laboratory indexes.
出处 《广州中医药大学学报》 CAS 2009年第3期213-217,共5页 Journal of Guangzhou University of Traditional Chinese Medicine
基金 广东省中医药管理局科研基金资助项目(编号:101120)
关键词 痴呆 多发性梗塞性/中药疗法 首灵健脑胶囊/治疗应用 DEMENTIA, MULTIPLE INFARCTION/TCD therapy SHOULING JIANNAO CAPSULE/therapeutic use
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