左氧氟沙星和呋喃唑酮根除幽门螺杆菌感染的疗效观察

THE CLINICAL OBSERVATION FOR ERADICATION OF HELICOBACTER PYLORI INFECTION WITH FURAZOLIDONE AND LEVOFLOXACIN

目的:比较含左氧氟沙星、呋喃唑酮的四联和三联疗法根除幽门螺杆菌(Hp)感染的疗效、安全性。方法:选择97例符合条件的Hp阳性的慢性胃炎和消化性溃疡的病人,随机分成两组,四联组采用奥美拉唑20mg、胶体果胶铋200mg、左氧氟沙星200mg、呋喃唑酮200mg,bid,口服10d;三联组除没有胶体果胶铋外,余项同。治疗结束4wk后,复查14C-尿素呼吸试验,观察Hp根除情况、症状及不良反应等。结果:根据意向处理分析(ITT)和试验方案分析(PP),四联组的Hp根除率分别为90.00%、91.83%,三联组的Hp根除率分别为74.00%、77.08%;四联组根除率较三联组明显高,差异有统计学意义(P<0.05)。四联组药物不良反应发生率为10.20%,三联组为10.42%,差异没有统计学意义(P>0.05)。结论:四联疗法Hp根除率高,是根除Hp的理想方案,可作为我区一线治疗选择。

Objective：To study the efficacy and safety of quadruple versus triple therapy with furazolidone and levofloxacin for eradication of Helicobacter pylori （Hp） infection. Methods： 97 cases with Hp infection suffering from chronic gastritis and peptic ulcer were randomized to quadruple therapy group and triple therapy group. The quadruple therapy group was administered omeprazole （20mg）, colloidal bismuth pectin （ 200mg）, levofloxacin （ 200mg）, furazolidone （ 200mg）, bis in die for 10 days ; while triple therapy group was the same except colloidal bismuth pectin. Four weeks later completion of the therapy, the ^14C -urea breath test was performed to evaluate the condition of Hp eradication, the symptoms and side - effects. Results： On the intention to treat analysis and the perprotoeol analysis, the eradication rates of Hp in quadruple therapy group are 90. 00% ,91.83% ;in triple therapy group are 74.00% ,77.08% ;the eradication rates of Hp in quadruple therapy group are higher than that of the triple therapy group,the difference is significant by statistics（ P 〈 0.05） ;The incidence of adverse drug reaction in the quadruple and triple therapy groups are 10. 20%, 10. 42% ,respectively with no significant difference. Conclution：The eradication rate of Hp in quadruple therapy group is higher than that of the triple therapy group, quadruple therapy is the correet choice for Hp eradication as the first - line treatment in our area.