1Seherer P E, Williams S, Fogliano M, et al. A novel serum protein similar to Clq, produced exclusively in adipocytes [J]. J Biol Chem,1995,270(45), 26746-26749.
2Hotta K, Funahashi T, Arita Y,et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients[J]. Arterioscler Thromb Vasc Biol, 2000,20 (6) : 1595-1599.
3Mori Y, Otabe S, Dina C, et al. Genome-wide search for type 2 diabetes in Japanese affected sib pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate loci on 7p and 11p[J]. Diabetes, 2002,51(4) : 1247-1255.
4Hu E, Liang P, Spiegelman B M. AdipoQ is a novel adiposespecific gene dysregulated in obesity[J]. J Biol Chem, 1996, 271(18) :10697-10703.
5Trujillo M E, Scherer P E. Adiponectin-journey from an adipocyte secretory protein to biomarker of the metabolic syn drome[J]. J Intern Med,2005, 257(2) : 167-175.
6HaraK,Boutin P,MoriY,et al.Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population [J]. Diabetes, 2002, 51(2):536-540.
8Zacharova J, Chiasson J L, Laakso M,et al. The common polymorphisms(single nucleotide polymorphism[SNP] +45 and SNP+ 276) of the adiponectin gene predict the conversion from impaired glucose tolerance to type 2 diabetes: the STOP NIDDM trial[J]. Diabetes,2005,54(3) :893-899.
2Hara K, Boutin P, Mori Y, et al. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population[J] .Diabetes,2002, 51 : 536.
3Yokota T, Oritani K, Takahashi I, et al. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the function of macrophages[J]. Blood, 2000, 96:1723.
4Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients[J]. Arterioscler Thromb Vasc Biol, 2000, 20:1595.
5Kondo H, Shimomura I, Matsukawa Y, et al. Association of adiponectin mutation with type 2 diabetes[J]. Diabetes, 2002,51 : 2325.
6Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia[J]. J Clin Endocrinol Metab,2001,86:1930.
7Hotta K, Funahashi T, Bodkin NL, et al. Circulation concentrations of the adipocyte protein, adipoenctin, are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys[J] . Diabetes, 2001, 50 :1126.
8Maeda N, Shimomura L, Kishida K, et al. Diet-induced insulin resistance in mice lacking adiponectin/Acrp 30[J]. Nat Med,2002, 8:731.
9Stumvoll M, Tschritter O, Fritsche A, et al. Association of the T - G polymorphism in adiponectin(exon2) with obesity and insulin sensitivity [J]. Diabetes, 2002, 51 : 37.
10Menzaghi C, Ercolino T, Paola RD, et al. A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome[J].Diabetes, 2002, 51:2306.
8Carlson CS, Eberle MA, Rieder MJ, et al. Selecting a maxi- mally informative set of set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet, 2004,74: 106-120.
9Hodle G, Muendlein A, Saely CH, et al. The-l1377 C>Gpromot- er variant of the adiponectin gene, prevalence ofcoronary atherosde- rosis, and incidence of vascular events in_men. Thromb Haemost, 2007,97:451-457.
10King H, Aubert RE, Herman WH, et al. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabe- tes Care, 1998, 21(9): 1414-1431.