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OSAHS与胰岛素抵抗的相关性研究 被引量:5

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摘要 目的研究OSAHS患者的睡眠呼吸紊乱指标与胰岛素抵抗(IR)程度的关系。方法选择OSAHS患者58例,另选57例非OSAHS患者作为对照。观察经皮血氧饱和度(SpO2),计算睡眠呼吸暂停低通气指数(AHI),次日监测结束后测空腹外周血胰岛素和血糖水平,采用胰岛素抵抗指数(HOMA-IR)评估IR程度。结果OSAHS组的HOMA-IR明显高于非OSAHS组,OSAHS组平均和最低SpO2明显低于非OSAHS组。OSAHS组HOMA-IR与AHI呈正相关,与最低SpO2呈负相关。结论OSAHS患者睡眠呼吸功能紊乱与IR有关,OSAHS可能经IR这一途径导致心血管疾病。
出处 《中国呼吸与危重监护杂志》 CAS 2009年第3期284-285,共2页 Chinese Journal of Respiratory and Critical Care Medicine
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  • 1Quinones MJ, Nicholas SB, Lyon CJ. Insulin resistance and the endothelium. Curr Diab Rep,2005 ,5 :246-253.
  • 2Ip MS, Lam B, Ng MM, et al. Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med,2002,165:670-676.
  • 3Punjabi NM, Ahmed MM, Polotsky VY, et al. Sleep-disordered breathing, glucose intolerance, and insulin resistance. Respir Physiol Neurobiol, 2003,136 : 167-178.
  • 4Punjabi NM, Shahar E, Redline S, et al. Resnick sleep-disordered breathing, glucose intolerance, and insulin resistance : the sleep heart health study. Am J Epidemiol,2004 ,160 :521-530.
  • 5Leprouh R, Copinschi G, Buxton O, et al. Sleep loss results in an elevation of cortisol levels the next evening. Sleep, 1997,20:865- 870.
  • 6Bratel T, Wennlund A, Carlstrom K. Pituitary reactivity, androgens and catecholamines in obstructive sleep apnoea. Effects of continuous positive airway pressure treatment. Respir Med, 1999, 93:1-7.
  • 7Cooper BG,White JE, Ashworth LA, et al. Hormonal and metabolic profiles in subjects with obstructive sleep apnea syndrome and the acute effects of nasal continuous positive airway pressure treatm ent. Sleep, 1995,18 : 172 - 179.
  • 8Saini J, Krieger J, Brandenberger G, et al. Continuous positive airway pressure treatment. Effects on growth hormone, insulin and glucose profiles in obstructive sleep apnea patients. Horm Metab Res, 1993,25:375-381.
  • 9Vgontzas AN, Papanicolaou DA, Bixler EO, et al. Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance,and hypercytokinemia. J Clin Endocrinol Metab, 2000, 85:1151-1158.
  • 10Barcelo A, Barbe F, Liompart E,et al. Neuropeptide Y and leptin in patients with obstructive sleep apnea syndrome : role of obesity. Am J Respir Crit Care Med, 2005,171 : 183-187.

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