五指毛桃镇咳及平喘作用研究

Study on the Antitussive and Antiasthmatic Effects of Radix Fici Hirtae

目的:观察五指毛桃镇咳及平喘的作用。方法:通过小鼠浓氨水引咳法、豚鼠枸橼酸引咳法、豚鼠组胺-乙酰胆碱超声雾化法、离体豚鼠气管平滑肌痉挛法及豚鼠过敏性休克法观察五指毛桃的镇咳平喘作用。结果:五指毛桃能明显减少氨水引发小鼠及枸橼酸引发豚鼠咳嗽反应的次数,并延长咳嗽潜伏期,对抗组胺-乙酰胆碱引起的豚鼠支气管哮喘,对磷酸组胺所致豚鼠离体气管平滑肌收缩有拮抗作用,并具有抗豚鼠过敏性休克的作用。结论:五指毛桃具有良好的镇咳及平喘作用。

Objective： To observe the antitussive and antiasthmatic effects of Radix Fici Hirtae （ RFH）. Methods： Antitussive effects were observed by ammonia water steaming test in mice and by citric acid test in guinea pigs. Antiasthmatic actions in guinea pigs were observed by histamine and acetylcholine ultrasonic atomization test,involved isolated guinea pig tracheal smoth muscle experiment and anaphylactic shock of guinea pigs. Results ： RFH decreased the frequency of cough induced by ammonia in mice and by citric acid in guinea pig,prolonged the latent period of cough and inhibited the experimental asthma by histamine and acetylcholine solution in conscious guinea pigs, antagonisted the contraction of tracheal smooth muscle by histamine phosphate in guinea pigs and could compete anaphylactic shock in guinea pigs. Conclusion： RFH has obvious antitussive and antiasthmatic effecets.