免疫球蛋白冲击疗法联合机械通气治疗小儿格林巴利综合征

CLINICAL OBSERVATION OF COMBINING PULSE THERAPY OF IMMUNOGLOBIN GAMA INJECTION AND MECHANICAL VENTILATION IN PEDIATRIC-PATIENT WITH THE GUILLAIN-BARRE SYNDROME

目的探讨大剂量静脉免疫球蛋白(IVIG)静脉滴注冲击疗法联合机械通气治疗小儿格林巴利综合征(GBS)的临床疗效。方法将48例小儿GBS患儿随机分成治疗组和对照组,治疗组在综合治疗基础上加用大剂量IVIG静脉滴注冲击疗法联合机械通气治疗。结果治疗组呼吸机与抗生素使用天数、ICU住院天数,ICU病死率均低于对照组,其差异有统计学意义(p<0.05)。结论大剂量IVIG静脉滴注冲击疗法联合机械通气治疗小儿GBS可靠、安全、副作用小,疗效显著。

Objective To investigate curative effect of combining pulse therapy of large dose Immunoglobin - Gama injection and Mechanical Ventilation in pediatric - patients with the Guillain - Barre syndrome （GBS）. Methods 48 such pediatric - patients were divided randomly into observation group and control group. All the pa- tients recieved Comprehensive Therapy, and the observation group added pulse therapy of Immunoglobin - Gama injection and Mechanical Ventilation at the same time. Results The observation group is lower than control group in the number of days to use antibiotic and to stay in ICU, as well as the fatality rate in ICU （p 〈 0.05 ）. Conclusion The therapy of combining pulse therapy of Immunoglobin - Gama injection and Mechanical Ventilation in pediatric - patient of Guillain - Barre syndrome is reliable and safe, as well as little side effect, and curative effect is significant.