2007年陕西省麻疹减毒活疫苗强化免疫效果评价

Effect evaluation of mass vaccination campaign with measles attenuated live vaccine in Shanxi Province in 2007

目的评估陕西省麻疹减毒活疫苗（measles attenuated live vaccine，MV）强化免疫的实施对控制麻疹发病的效果，为消除麻疹工作提供对策依据。方法利用2005～2008年大疫情报告麻疹发病资料、人群麻疹抗体监测资料、强化免疫前后MV免疫史调查资料，探讨MV强化免疫的效果。结果MV强化免疫后，8月龄～14岁人群的有MV免疫史率较强化免疫前显著上升；8月龄～14岁人群强化免疫后的麻疹IgG抗体几何平均滴度（GMC）和阳性率分别为2270．38±3．02mIU／ml和98．68％，显著高于该人群强化免疫前的GMC（1465．53±4．51mIU／m1）（t=6．86，P〈0．01）和阳性率（89．78％）（χ^2=32．14，P〈0．01）；与强化免疫前的2005～2007年相比，2008年陕西省麻疹发病率显著下降。结论2007年陕西省MV强化免疫效果显著，已经建立了麻疹免疫屏障，但陕西省基础免疫工作中存在着MV免疫不及时的薄弱环节，急待加强。

Objective To evaluate the effect of mass vaccination campaign（MVC） with MV in Shanxi Province on measles control and provide the basis of strategy for measles elimination. Methods The data on measles incidence during 2005 - 2008 were collected, which were reported through monitoring system of infectious disease. At the same time, the data on measles antibody level detected for 8 mon - 14 yrs age group and MV vaccination history investigated before MVC and after were used. Results The rate of MV vaccination investigated after MVC was significantly higher than that of MVC before. The GMC of measles antibody and seropostive rate for 8 mon - 14 yrs age group were 2 270.38 ±3.02 mIU/ml and 98.68%, respectively after MVC. Before MVC the GMC of measles antibody and seropostive rate for 8 mon - 14 yrs age group were 1 465.53 ± 4.51mIU/ ml and 89.78%. The GMC after MCV was higher than that of MCV before（ t = 6.86, P 〈 0. 0001） and the seropostive rate after MCV was also higher than that of MCV before（χ^2= 32.14, P 〈 0.001） .Compared with the measles in- cidence in Sbanxi Province from 2005 to 2007 , the measles incidence in 2008 decreased significantly. Conclusion MCV conducted in Shanxi Province in 2007 attended with good results. Immuno - barrier of measles for the public has been established. The weak link in routine vaccination in Shanxi Province was that the first dose of MV could not been injected timely, and this situation should be improved.