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DNA去甲基化与肿瘤治疗的研究进展 被引量：5

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摘要 近年来大量的研究结果显示，肿瘤的发生不但存在遗传学上的改变，而且存在表观遗传学的改变。遗传学改变是指基于基因序列改变而导致基因表达水平的变化，如基因突变、杂合性缺失、微卫星不稳定性等。表观遗传学是非基因序列改变所导致的基因水平的变化，如组蛋白修饰、染色质重塑、DNA甲基化等染色质结构上的变异。其中DNA甲基化异常已成为DNA突变、缺失以外导致抑癌基因失活的第三大机制，主要表现为肿瘤细胞中普遍性低甲基化和CpG岛区域性高甲基化。
作者 王欣欣 付丽
机构地区 天津医科大学附属肿瘤医院乳腺病理研究室教育部乳腺癌防治重点研究室教育部长江学者奖励计划“中国女性乳腺癌发生、转移机制及防治的研究”创新团队天津市肿瘤防治重点研究室
出处 《中华病理学杂志》 CAS CSCD 北大核心 2009年第5期355-357,共3页 Chinese Journal of Pathology
基金 基金项目：863重大项目课题支持（2006AA02A249）
关键词 DNA甲基化异常 肿瘤治疗 去甲基化 表观遗传学 微卫星不稳定性 基因表达水平 基因序列 遗传学改变
分类号 R686 [医药卫生—骨科学]
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参考文献16

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共引文献4

同被引文献54

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引证文献5

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中华病理学杂志
2009年 第5期

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