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蛋白CXCR7的发现及其作用 被引量：6

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摘要 CXCR7，以前称为RDC1，1989年从狗甲状腺cDNA库筛选出来的，最初报道是一个具有血管活性肠肽（VIP）的受体，接着被确定为与降钙素基因相关肽结合的受体，后来又认为与肾上腺髓质素结合，然而这些定论最终都被否决了。事实上，RDC1与已知的一些趋化因子受体有高度相似序列，故属于G蛋白耦联受体（G-protein coupled receptor，GPCR）的亚族。然而因为不知道或者认为没有配体故一直将RDC1归类为孤儿GPCR。最近研究提出RDC1与CXCR4分享配体基质细胞衍生因子1／趋化因子配体12（SDF1／CXCL12），
作者 沈勤 王芳
机构地区 云南省昆明医学院病理学教研室
出处 《中华病理学杂志》 CAS CSCD 北大核心 2009年第5期358-360,共3页 Chinese Journal of Pathology
关键词 G蛋白耦联受体 趋化因子受体 趋化因子配体 基质细胞衍生因子1 降钙素基因相关肽 receptor 血管活性肠肽 肾上腺髓质素
分类号 R686 [医药卫生—骨科学]
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参考文献22

  • 1Infantino S, Moepps B, Thelen M. Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells. J Immunol,2006,176 (4) : 2197-2207.
  • 2Jones SW, Brockbank SM, Mobbs ML, et al. The orphan G-protein coupled receptor RDCI: evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover. Osteoarthritis Cartilage, 2006,14 ( 6 ) : 597 -608.
  • 3Sierro F, Biben C, Marttnez-Munoz L, et al. Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci U S A ,2007,104 ( 37 ) : 14759-14764.
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  • 5Proost P, Mortier A, Loos T, et al. Proteolytic processing of CXCLll by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration. Blood ,2007,110( 1 ) :37-44.
  • 6Burns JM, Summers BC, Wang Y, et al. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, celladhesion, and tumor development. J Exp Med, 2006,203 ( 9 ) : 2201-2213.
  • 7Wang J, Shiozawa Y, Wang J, et al. The role of CXCRT/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. J Biol Chem ,2008,283 (7) :4283-4294.
  • 8Watt SM,Forde SP. The central role of the chemokine receptor, CXCR4, in haemopoietic stem cell transplantation: will CXCR4 antagonists contribute to the treatment of blood disorders? Vox Sang,2008,94( 1 ) : 18-32.
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同被引文献78

  • 1祝先进,苏东辉.一种新的趋化因子I-TAC[J].国际免疫学杂志,2006,29(5):330-334. 被引量：7
  • 2漆楚波,朱润庆,夏和顺,王明伟.组织芯片简易制作方法及免疫组化有效性分析[J].肿瘤防治研究,2007,34(8):629-632. 被引量：17
  • 3Wang J,Wang J,Sun Y,et al.Diverse signaling pathways through the SDF-1/CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis.Cell Signal,2005,17(12):1578-1592.
  • 4Jones SW,Brockbank SM,Mobbs ML,et al.The orphan G-protein coupled receptor RDC1:evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover.Osteoarthritis Cartilage,2006,14 (6):597-608.
  • 5Boldajipour B,Mahabaleshwar H,Kardash E,et al.Control of chemokine-guided cell migration by ligand sequestration.Cell,2008,132(3):463-473.
  • 6Iwakiri S,Mino N,Takahashi T,et al.Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsmall cell lung cancer.Cancer,2009,115(11):2580-2593.
  • 7Vicari A P,Caux C.Chemokines in cancer[J].Cytokine Growth Factor Rev,2002,13(2):143-54.
  • 8Infantino S,Moepps B,Thelen M.Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells[J].J Immunol,2006,176(4):2197-207.
  • 9Jones S W,Brockbank S M,Mobbs M L,et al.The orphan G-protein coupled receptor RDC1:evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover[J].Osteoarthritis Cartilage,2006,14(6):597-608.
  • 10Boldajipour B,Mahabaleshwar H,Kardash E,et al.Control of chemokine-guided cell migration by ligand sequestration[J].Cell,2008,132(3):463-73.

引证文献6

二级引证文献12

中华病理学杂志
2009年 第5期

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