妊娠妇女RDW与血清叶酸变化及其临床意义

The Clinical Significance of the Serum Folic Acid and RDW Levels in Pregnant Women

目的探讨妊娠妇女红细胞体积分布宽度(RDW)与血清叶酸变化及其临床意义。方法随机选择2008年1月—12月正常妊娠妇女225例作为观察组,孕早、中、晚期各75例,同期健康体检的非妊娠妇女225例作为对照组,比较两组及妊娠各期红细胞(RBC)、血红蛋白(Hb)、RDW、叶酸的变化。结果观察组血清叶酸、Hb水平、RBC计数低于对照组,而RDW则高于对照组(P<0.05),随着孕期的延长叶酸、Hb、RBC水平进行性下降,RDW进行性升高,各期比较有显著性差异(P<0.05)。结论整个妊娠期血清叶酸低,并随妊娠进展降低,血清叶酸、RDW呈一定的反相关,通过对孕妇叶酸、RDW的测定,判断妊娠期妇女贫血的类型,推测引起孕期贫血发生的可能原因,是一种简单易行的诊断方法,对于孕期贫血临床治疗有一定的指导意义。

OBJECTIVE Clinical significance of the serum folic acid and RDW levels in pregnant women. METHODS The 225 normal pregnant women were equally derided into 3 groups which inearly middle, later period at random between January. 2008 and November 2008. The 225 normal pregnant women were in the contrast group. The serum folic acid, RBC, Hband RDW levels were detected in 225 normal pregnant women and 225 normal women. RESULTS The serum folio cid ,Hb and RBC levels in normal pregnant women were sign ficantly lower than normal women .The RDW levels were ignificantly higher than normal women （P〈0.05） .The serum folic cid, Hb and RBC levels gradually increased and the RDW level gradually decreased （P〈0.05）, while the pregnancy was getting longer. CONCLUSIONS The pregnant women have deficiency the folic acid during pregnancy. The serum folic cid gradually decreased while the pregnancy was getting longer. There was negative correlation between the serum folic acid and RDW levels. We can determine the type- of anemia of pregnant women, and speculate the cause of anemia bv determining the serum folic acid and RDW levels.